Top Sector Life Sciences & Health (LSH) entails a broad scope of disciplines, from pharmaceuticals to medical technology and from healthcare infrastructure to vaccination. To realise its mission – vital citizens in a healthy economy - the Top Sector builds on the strengths of the Dutch LSH sector to address the biggest societal challenges in prevention, cure and care. By funding multidisciplinary public-private partnerships (PPPs) the Top Sector aims to facilitate innovation. Here we give an overview of  a number of funded R&D projects by Top Sector LSH. The page is updated continuously.

Bactericidal Coating on Complex Titanium Implants

Bactericidal Coating on Complex Titanium Implants (BCCTI)

Bactericidal Coating on Complex Titanium Implants (BCCTI) is conclusion of a recently successful partnership of UMC Utrecht, Health~Holland and Amber Implants BV to tackle one of the most important challenges of orthopedic surgery: Implant-associated infections (IAIs).

IAIs occur in approximately 1-2% of all primary (first) implant surgeries and up to 8% of revision surgeries. IAIs can be devastating for patients, with long hospitalisation, high costs, and extensive operative procedures to remove the biofilm and replace the implant. In the Netherlands, the number of these infected implants are estimated at 1500 per year, with an annual hospitalisation cost of approximately €75 million.

BCCTI will optimise the parameters of electrophoretic deposition technology (EPD) technique in order to make a uniform and consistent antibacterial coating on geometrically complex and porous titanium implants. To apply the proposed approach, they will use EPD technology which accounts for a polymeric coating on the huge surface area of 3D printed volume-porous implants to release antibacterial agents. Once the coating functionality verified in vitro, an animal infection model will be employed to monitor in vivo behaviour of the developed coating.

Finally, the project should facilitate the pre-clinical steps needed to promote this technology and later bring it to the market. This can be realised by optimising implant fabrication, decrease of the surgery duration and post-surgical activities.