Top Sector Life Sciences & Health (LSH) entails a broad scope of disciplines, from pharmaceuticals to medical technology and from healthcare infrastructure to vaccination. To realise its mission – vital citizens in a healthy economy - the Top Sector builds on the strengths of the Dutch LSH sector to address the biggest societal challenges in prevention, cure and care. By funding multidisciplinary public-private partnerships (PPPs) the Top Sector aims to facilitate innovation. Here we give an overview of  a number of funded R&D projects by Top Sector LSH. The page is updated continuously.

Improving endovascular treatment for aneurysm

On evaluating stent-artery interaction in abdominal aortic stent grafting

Abdominal aortic aneurysm – a localised dilation of the abdominal aorta – is a common disorder. If this bulge in the aorta grows and remains untreated it may lead to rupture of the vessel wall, causing internal bleeding. Various studies have shown that treating aortic aneurysm using EVAR – implanting a stent-graft via the groin – gives better short-term results than the more invasive method of open surgery. However, in the long term 10 to 20% of these patients need a second intervention to preserve EVAR. Little is known about the aortic-stent-graft dynamics once implanted, while this is highly relevant for the design of stent-grafts and for clinical decision making.  

This research project was established as a collaboration between the University of Twente and Terumo Aortic to develop methods that advance the understanding of stent-graft behaviour in patients after endovascular aneurysm repair (EVAR). In this research project a method was developed, validated and applied to patient data to examine the interaction between the stent-graft and the aortic vessel, on the basis of heartbeat-coupled CT scans.  

The insights provided contribute to improved decision-making in the selection, positioning and monitoring of stent-grafts. They can also lead to modifications in stent-graft design, which could reduce the incidence of complications in the future. This work supports the development of more realistic preclinical tests and more durable stent-grafts, which can improve treatment outcome and reduce health care costs.