Food supplements to boost brain function – mind your blood vessels
Age-related chronic diseases including dementia, type-2 diabetes and cardiovascular disease become more prevalent and of increasing societal concern. Common denominators of these co-morbidities are insulin-resistance and impaired vascular function. Newtricious (NWT)-03 is a novel egg-protein hydrolysate that has proven benefits on insulin-sensitivity and peripheral vascular function, which are risk markers for T2DM and CVD. Insulin-resistance is also associated with cognitive decline, while impaired brain vascular function is a key event preceding the development of impaired cognitive performance. It is already shown that some short-term beneficial effects of NWT-03 on cognitive performance, but underlying mechanisms were not addressed, and long-term effects still remain unknown. Therefore, the hypothesis is that the novel egg-protein hydrolysate NWT-03 beneficially affects brain vascular function and cognitive performance following long-term daily intake.
Within this study, the effect of NWT-03 on cerebral blood flow will be investigated as a marker of brain vascular function. For this, a randomised, placebo-controlled intervention study in forty overweight or obese adults (aged 60-70) with subjective cognitive decline (SCD) will be performed. SCD has emerged as a pre-mild cognitive impairment (pre-MCI) at risk condition of dementia. Participants will receive daily 5.0 g of NWT-03 or a placebo for 36 weeks. Non-invasive MRI methods will be used to investigate brain vascular function, while there will be a focus on NWT-03-induced changes on cognitive performance. Exploratory objectives are to study long-term effects on other potential mechanisms responsible for observed effects on cognitive performance, and other perceivable benefits. This project will advance the understanding of why NWT-03 is beneficial for cognitive impairment and possibly other age-related conditions. Except for its scientific relevance, results will contribute to other important areas such as the reduction of economic and societal costs related to cognitive decline.