ADVanced Image Supported lEft ventricular lead placement in Cardiac Resynchronization Therapy

ADVanced Image Supported lEft ventricular lead placement in Cardiac Resynchronization Therapy: ADVISE-CRT III

The CARTBox platform is a technique that helps cardiologists place the pacemaker wire of the cardiac resynchronization therapy (CRT) pacemaker at the optimal location in the heart to improve the outcomes of therapy. The CARTBox platform consists of a cloud based component for MRI image postprocessing, and a image guidance tool in the cardiac catheterization room which helps cardiologists to place the pacemaker wire of the cardiac resynchronization therapy (CRT) pacemaker at the optimal location in the heart to improve the outcomes of therapy. We worked with cardiologists and patients to further develop and test the CARTBox platform. Ultimately, 7 hospitals participated in this randomized controlled multicenter study using this technique. All these hospitals were trained in the use of the CARTBox platform. Due to some delays in patient inclusion, the duration of the study had to be extended to include a total of 130 patients. All data is now available for analysis and the results can be shared at conferences. In addition, we also looked at the broader impact of the CARTBox platform on healthcare costs. Based on a predictive model, the use of the CARTBox platform for implants would lead to better CRT outcomes and lower healthcare costs. This will be verified with the data from the current study. Finally, plans are already being made for additional research to make the CARTBox platform more widely applicable. 

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Summary
Cardiac Resynchronization Therapy (CRT) is a therapy for heart failure patients. Unfortunately in 30% of patients CRT does not have an effect. A major reason is the implantation location of the left ventricular electrode. We have investigated the added value of the CARTBox platform for image guided CRT pacemaker implantations
Technology Readiness Level (TRL)
7 - 7
Time period
48 months
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