Discover our projects

Since 2013, Health Holland has supported more than 1,719 public-private R&D projects. Together, these projects represent more than €2 billion in investment in research and innovation. In this way, we bring togethercompanies, research organizations, healthcare organizations and other stakeholders to develop innovative solutions to the challenges of today and tomorrow.

The projects originate from programs and thematic funding rounds and focus on a wide range of themes within the Life Sciences & Health (LSH) sector. By pooling knowledge, expertise and investment, these projects accelerate the development and practical application of innovations.

From medical technology and drug development to digital healthcare and prevention: every project contributes to a strong LSH ecosystem and better health and care.

Explore our project portfolio below and discover how public-private partnerships accelerate innovation in practice.

Status
Funding year
Mission
Theme
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AI for rapid identification of brain tumors during surgery

Development and Implementation of Software for Classification of brain tumours Using real-time methylation Sequencing (DISCUS)

2025
Ultra-fast diagnosis of brain cancer during surgery with DNA analysis and AI
Actief
,mission-iii-participating-with-a-disease-or-disability,
,cure,life-science-and-biotechnologies,medical-technology,molecular-diagnostics,
Micro Cancer Lab: Testing New Treatments for Lymphoma

Development of a lymphoma-on-chip model for testing therapeutic strategies LYMPHOMACHIPTHERA

2024
Revolutionizing lymphoma treatment with a cutting-edge on-chip model, accelerating breakthroughs for targeted therapies
Archief
,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,cure,enabling-technologies,engineering-and-fabrication-technologies,life-science-and-biotechnologies,pharmacotherapy,
Precision nutrition based on metabolic subgroups leads to clinically relevant further improvements in insulin sensitivity and cardiometabolic health

Precision Nutrition in the prevention of chronic metabolic diseases

2023
Precision nutrition based on metabolic subgroups leads to clinically relevant further improvements in insulin sensitivity and cardiometabolic health
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,
,healthcare,life-science-and-biotechnologies,one-health,prevention,specialized-nutrition,
Personalized mass spectrometry to improve diagnostics of hematological cancers

PRIME-TIME: Personalized mass spectrometry as novel standard for minimal invasive M-protein diagnostics

2023
PRIME-TIME develops personalized minimal invasive diagnostics to predict, prevent and monitor disease-activity of hematological cancers.
Actief
,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,
,care,enabling-technologies,healthcare,life-science-and-biotechnologies,molecular-diagnostics,
Following cancer cells spreading to bone in small microfluidic devices

Bone Metastasis chip with micro-physiological circulation for cancer profiling (OSCAR)

2023
A bone-metastasis-chip (OSCAR) with a recirculation system (CRIS) is developed to recapitulate the passage of cancer cells from the blood to bone in order to understand what mechanisms support bone metastasis formation and can ultimately be exploited for therapy
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,cure,enabling-technologies,life-science-and-biotechnologies,molecular-diagnostics,
Blood cancer

Validation of newly identified targets in AML

2018
The efficacy of newly identified targets in AML in vitro and in vivo will be evaluated
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,
,bio-pharma,cure,enabling-technologies,molecular-diagnostics,

Het samen ontwikkelen van digitale communicatieplatforms in ondersteuning en zorg vanuit cliëntenperspectief van mensen die langer thuis willen wonen.

2021
Nieuwe kennis over het gebruik van digitale platforms zal worden gebruikt voor cliëntgerichte ontwikkeling van nieuwe platforms.
Archief
,mission-ii-care-in-the-living-environment,
,care,digital-and-information-technologies,enabling-technologies,health-technology-assessment-and-quality-of-life,healthcare,homecare,prevention,
Logo

Design of effective synthetic long peptide (SLP)-based therapeutic capable of inducing an effective immune response against hepatitis B virus-infected cells by avoiding immune tolerance and viral resistance

2016
SLP based immunotherapy may offer functional cure for millions of people worldwide suffering from chronic hepatitis B
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,cure,global-health,life-science-and-biotechnologies,pharmacotherapy,
hearing

Enhancing perception of speech in multi-talker conversations for deaf individuals by optimising cochlear implants

2014
What factors limit speech perception in cochlear-implant users, and how do we overcome these with technical solutions
Archief
,care,enabling-technologies,healthcare,regenerative-medicine,
Global access to digits-in-noise hearing tests

Global access to digits-in-noise hearing tests: a fully automatic test development procedure (Aladdin)

2019
Aladdin is a cost-effective, efficient solution for hearingtest development, also for low- and middle-income countries
Archief
,mission-ii-care-in-the-living-environment,
,care,digital-and-information-technologies,global-health,healthcare,homecare,medical-technology,
Combining health claim data with routine clinical care data

Use and linkage of data for health research without consent: recommendations for health care providers, insurance companies and research institutes

2020
Recommendations for linkage of data for health researcH
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,
,digital-and-information-technologies,enabling-technologies,healthcare,one-health,prevention,
High throughput mini muscles

Development of a high throughput 3-dimensional muscle-on-chip model

2019
In this project, a method was developed to measure contractile force of multiple muscles on a chip simultaneously
Archief
,mission-iii-participating-with-a-disease-or-disability,
,enabling-technologies,engineering-and-fabrication-technologies,healthcare,prevention,regenerative-medicine,
Long-term Clinical utility of amyloid-PET in an unselected memory clinic cohort

Long-term Clinical utility of amyloid-PET in an unselected memory clinic cohort

2019
Using advanced statistical methods ABIDE-clinical utility studied in which patients amyloid PET yields health benefits
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iv-quality-of-life-for-people-with-dementia,
,care,health-technology-assessment-and-quality-of-life,healthcare,imaging,life-science-and-biotechnologies,
CRISPR-Cas9: from a molecular scissor to a surgical knife

Improving the CRISPR-Cas9 genome editing tool

2018
CRISPR-Cas9: optimised, accurate and safe!
Actief
,mission-iii-participating-with-a-disease-or-disability,
,cure,life-science-and-biotechnologies,medical-technology,pharmacotherapy,regenerative-medicine,
NOX: Radiation-Free Guidewire Navigation for Safer Vascular Procedures

NOX: Radiation-Free Magnetic Guidewire Localization for Vascular Interventions

2026
Replacing radiation with magnetic tracking to make vascular guidewire navigation safer for everyone
Actief
,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,
,care,digital-and-information-technologies,imaging,key-enabling-technologies,medical-technology,
Pregnancy Hyperglycemia & Offspring Metabolic Syndrome (PHOMS)

Consequences of maternal diabetes during pregnancy for offspring health

2020
Preclinical studies to investigate metabolic disease risk and -development in offspring born from diabetic pregnancies
Archief
,bio-pharma,molecular-diagnostics,prevention,specialized-nutrition,
AQrate assessment of Extracellular Vesicle-miRNAs

A quantitative and qualitative assessment of Extracellular Vesicle-miRNAs for signature discovery in liquid biopsies (AQrate)

2020
Reducing technical and biological noise to unleash the promise of cell-free miRNAs as liquid biopsy
Archief
,mission-iv-quality-of-life-for-people-with-dementia,
,cure,enabling-technologies,life-science-and-biotechnologies,molecular-diagnostics,
vitro patient avatars

MOS-Select: MicroOrganoSpheres® as 3D in vitro patient avatars for personalized cancer therapy selection

2025
We will use unique technology to predict patient-unique responses to cancer treatments, in primary and metastatic tumors
Actief
,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,care,cure,life-science-and-biotechnologies,molecular-diagnostics,pharmacotherapy,
Personalized treatment for rheumatoid arthritis patients

Personalized treatment using anti-IgA-receptor blocking antibodies for rheumatoid arthritis patients with IgA mediated disease

2025
Selection of RA-patients with IgA-mediated disease who are eligible for therapy targeting the IgA-receptor (CD89)
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,care,kind-of-research,life-science-and-biotechnologies,molecular-diagnostics,pharmacotherapy,
A simple dietary approach to counteract type 1 diabetes progression

NOvel MIcrobiome Therapeutics to limit autoimmunity and improve glycaemic control in type 1 diabetes mellitus ( NOMIT)

2025
Targeting gut microbiota to limit autoimmunity in type 1 diabetes mellitus
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,cure,homecare,life-science-and-biotechnologies,specialized-nutrition,
Developing self-regulating gene therapy for neurodegenerative diseases

Developing neuroinflammation-directed precision AAV gene therapy for neurodegenerative diseases

2025
Developing self-regulating gene therapy for neurodegenerative diseases
Actief
,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,cure,life-science-and-biotechnologies,regenerative-medicine,
apparatuur

Continuous Flow PEritoneal DIalysis System (COPEDIS)

2019
Innovation in peritoneal dialysis offers opportunities for kidney patients: first clinical study successfully launched
Archief
,mission-i-lifestyle-and-living-environment,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,mission-iv-quality-of-life-for-people-with-dementia,
,care,cure,homecare,life-science-and-biotechnologies,medical-technology,
A natural RNA therapeutics delivery system for cancer treatment

NEXT - Nucleic acid delivery by bioengineered extracellular vesicles for prostate cancer treatment

2023
This project will develop bioengineered extracellular vesicles as a proof of concept novel modality to deliver therapeutic anticancer nucleic acids. We will optimize scalable bioreactor production and establish their bioactivity in vitro. Efficacy and biodistribution will be evaluated in preclinical animal models of prostate cancer.
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,mission-iv-quality-of-life-for-people-with-dementia,
,bio-pharma,cure,enabling-technologies,life-science-and-biotechnologies,pharmacotherapy,
Development of artificial intelligence driven F-18-Fluoride PET/CT analysis of bone and joint pathology in spondyloarthritis and beyond

Using artificial intelligence to train computers to analyse PET/CT scans of bone and joint abnormalities in spondyloarthritis.

2023
Development of automated PET/CT scan analysis for fast and accurate diagnosis and monitoring of spondyloarthritis
Actief
,mission-iii-participating-with-a-disease-or-disability,
,care,digital-and-information-technologies,imaging,medical-technology,molecular-diagnostics,
Targeted detection and characterisation of chromosomal breakpoints in colorectal cancer

Target:SVs - Targeted detection and functional characterisation of chromosomal breakpoint structural variants in colorectal cancer: advancing towards biomarker assay development

2021
Develop assays detecting DNA structural variants, characterise functional consequences in organoids, translate into cancer biomarkers
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,
,care,healthcare,life-science-and-biotechnologies,molecular-diagnostics,
Logo

Bone metastasis “in a dish”: engineering vascularised bone in vitro to model metastatic breast cancer; BoneMeND

2021
Growing bones in the laboratory to investigate the mechanisms of bone metastasis
Actief
,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,cure,life-science-and-biotechnologies,pharmacotherapy,regenerative-medicine,
One-stop breath analyser for better care to vulnerable patients

Decreased deployment of medical resources by applying the one-stop breath analyser in vulnerable patients with chronic diseases

2021
The innovative one-stop breath analyzer decreases deployment of medical resources
Archief
,mission-iii-participating-with-a-disease-or-disability,
,care,global-health,healthcare,molecular-diagnostics,nanotechnology,
Logo

PLINT (Preventief Leer- en InnovatieNetwerk Tegen) Ondervoeding

2021
Preventie van ondervoeding bij ouderen door het verbeteren van voorlichting in de thuiszorg, het innoveren van voedselconcepten en het vergroten van bewustwording
Archief
,mission-i-lifestyle-and-living-environment,mission-ii-care-in-the-living-environment,
,homecare,prevention,specialized-nutrition,
dementia

ABIDE Communication: Shared decision making in dementia diagnosis in the era of amyloid imaging

2017
ABIDE communication developed best practices for communication in the diagnostic process of AD
Archief
,mission-iv-quality-of-life-for-people-with-dementia,
,health-technology-assessment-and-quality-of-life,healthcare,life-science-and-biotechnologies,molecular-diagnostics,prevention,
blood

Engineering procoagulant variants of blood coagulation factor X for therapeutic purposes

2021
Engineering variants of blood coagulation factor X for the prevention and treatment of bleeding
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,cure,enabling-technologies,nanotechnology,pharmacotherapy,
Lentiviral biological pacemakers

LentiPace II validates and implements functional studies for creating biological pacemakers with long-term function using lentiviral-based gene therapy

2019
Creation of a biological cardiac pacemaker using gene therapy
Actief
,cure,medical-technology,regenerative-medicine,
Blood-biomarkers for early detection of Alzheimer’s Disease

Diagnostic and prognostic value of blood-biomarkers for early detection of Alzheimer’s Disease pathology

2019
The search towards an easy applicable blood-biomarker for accurate detection of Alzheimer’s disease pathology
Archief
,health-technology-assessment-and-quality-of-life,healthcare,molecular-diagnostics,prevention,
A novel approach for the management of taste disorders in cancer patients

Photobiomodulation therapy, a novel approach for the management of taste disorders in cancer patients? The LI-TASTE study (Light for TASTE)

2022
Can photobiomodulation therapy prevent chemotherapy related taste disorders in patients with multiple myeloma?
Archief
,mission-iii-participating-with-a-disease-or-disability,
,cure,health-technology-assessment-and-quality-of-life,healthcare,photonics-and-optical-technologies,regenerative-medicine,
A new woman-friendly self-test to detect endometrial cancer

Endometrial cancer detection using DNA methylation: ENDO-MET study

2025
Early detection of endometrial cancer with a non-invasive woman-friendly self-test, based on DNA methylation markers
Actief
,mission-i-lifestyle-and-living-environment,mission-ii-care-in-the-living-environment,
,cure,healthcare,homecare,life-science-and-biotechnologies,molecular-diagnostics,
cardiac gene therapy

Nano-PLNCARE: Nanoparticle-based PhosphoLambaN CArdiac REpair

2025
Improved cardiac gene therapy efficiency for treating PLNcardiomyopathy through a novel delivery technology
Actief
,mission-iii-participating-with-a-disease-or-disability,
,cure,enabling-technologies,life-science-and-biotechnologies,regenerative-medicine,
Target to B!

4. Target to B! - Towards patient-tailored immunotherapy to effectively treat B-cell associated disease

2018
This public-private project was aimed to understand B-cell disease by disease-overarching comparisons of different antibody-mediated diseases, analysis of antibody and B-cell receptor specifics, and the variable response to immunotherapy.
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,missie-v-better-protection-against-health-threats,mission-iii-participating-with-a-disease-or-disability,
,care,enabling-technologies,healthcare,life-science-and-biotechnologies,molecular-diagnostics,prevention,
Fit for the future: the Vital Craftmanship Action Program

Vital Craftmanship Action Program: sustainable health and employability for practically trained technicians

2018
Supporting organizations to reverse mental retirement and to restore the fit between employees and work
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,
,health-technology-assessment-and-quality-of-life,healthcare,homecare,prevention,
Proof of concept for peptide-based treatment against osteoarthritis

PEP DMOAD; Proof of concept for a peptide-based disease-modifying osteoarthritis drug candidate

2022
The next step in development and proof of concept for a peptide-based disease-modifying osteoarthritis drug candidate
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,mission-iv-quality-of-life-for-people-with-dementia,
,bio-pharma,cure,pharmacotherapy,regenerative-medicine,
The Netherlands Network for Difficult-To-Treat Depression

The Netherlands Network for Difficult-To-Treat Depression: Towards a better positioning of novel pharmacological treatment

2023
State of the art research and data science to improve clinical care for depression
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,
,cure,digital-and-information-technologies,healthcare,molecular-diagnostics,pharmacotherapy,
Scan2Go: Autonomous MRI for large scale diagnostics of brain integrity

Scan2Go: Autonomous MRI for large scale diagnostics of brain integrity

2023
Perception study of low-cost automatic self-scan MRI with article intelligence that translates images to diagnose
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,
,care,enabling-technologies,engineering-and-fabrication-technologies,imaging,medical-technology,
Periodic use of a fasting-mimicking diet in type 2 diabetes

Integrating a fasting-mimicking diet program in regular primary care promotes regression of type 2 diabetes; results of a 12- month randomised, controlled, assessor-blinded study

2017
Periodic use of a fasting-mimicking diet as an adjunct to regular care improves glycemic management in type 2 diabetes patients
Actief
,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,
,cure,healthcare,specialized-nutrition,
Muscle exercise in a muscle-on-a-chip model

Noninvasive analysis of muscle-on-a-chip: increased throughput, exercise modules, and application to muscle disease

2023
Human healthy and diseased miniature muscles will be grown and exercised on a chip
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,enabling-technologies,life-science-and-biotechnologies,prevention,regenerative-medicine,
Logo

Study to investigate anti-inflammatory effects of Glycopyrronium in asthma

2019
PANTANI study to investigate anti-inflammatory effects of Glycopyrronium in asthma
Actief
,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,healthcare,molecular-diagnostics,pharmacotherapy,prevention,
Sleep

REconsidering nocturnal non-invasive ventilation in COPD patients with stable hypercAPnic respiraTory failURE (Recapture)

2017
This study investigates if NIV stabilises the lung function via beneficial effects on inflammation and repair pathways
Archief
,mission-iii-participating-with-a-disease-or-disability,
,care,health-technology-assessment-and-quality-of-life,healthcare,homecare,medical-technology,
Artificial intelligence in scans for deciding quickly on stroke treatment

STAIRS: Stroke treatment decision support by Artificial Intelligence for analysis of Magnetic Resonance images

2019
Fast AI-based MRI acquisition and image analysis can support treatment decision in stroke
Actief
,cure,enabling-technologies,imaging,medical-technology,
Curing HIV-1 by eliminating its hiding place

Towards a HIV-1 cure; identification and elimination of the HIV-1 reservoir

2019
Eliminating the HIV-1 reservoir to achieve a HIV-1 cure
Actief
,bio-pharma,cure,molecular-diagnostics,pharmacotherapy,
T cell receptor gene therapy for leukemia patients

T cell receptor gene therapy for patients with relapsed or persistent hematologic disease after allogeneic stem cell transplantation

2019
A Phase I/II clinical study will be performed to test T cell receptor gene therapy for patients with leukemia
Archief
,cure,enabling-technologies,healthcare,pharmacotherapy,
Growing real human small blood vessels in the laboratorium

STABILISE: Human pericyte-stabilised three dimensional microvessels on-a-chip

2019
Generating true capillaries with endothelial cells and supporting pericytes
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,
,enabling-technologies,healthcare,prevention,regenerative-medicine,
Assessment of pancreatic islet growth by automated imaging

Creation of an automated multiwell technology platform to assess pancreatic islet growth

2017
This project aims to create a multiwell technology platform to asses pancreatic islet growth by imaging techniques
Archief
,care,imaging,medical-technology,regenerative-medicine,
DIgitale Gepersonaliseerde Nazorg na een opname op de Intensive Care afdeling

DIgitale Gepersonaliseerde Nazorg na een opname op de Intensive Care afdeling: DIGNIC

2022
"Op de IC ben je alle regie kwijt, daarna wil je dat terug" De IC-herstelwijzer als gedigitaliseerd, gepersonaliseerd IC-nazorg platform helpt daarbij
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,
,care,digital-and-information-technologies,health-technology-assessment-and-quality-of-life,homecare,medical-technology,
INSPIRATION: Image-based aspiration catheter sizing in acute ischemic stroke

INSPIRATION: Acute stroke treatment catheterer sizing

2026
About time that we introduce personalized treatment for acute ischemic stroke
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,
,cure,digital-and-information-technologies,enabling-technologies,imaging,medical-technology,
Alzheimer Digital: Advancing Dementia Diagnostics

Advancing Digital Cognitive and Functional To Improve Early Diagnosis of Alzheimer’s Disease (Alzheimer Digital)

2026
AI-powered digital tools for earlier, personalised Alzheimer’s diagnostics and care
Archief
,mission-ii-care-in-the-living-environment,mission-iv-quality-of-life-for-people-with-dementia,
,care,digital-and-information-technologies,homecare,medical-technology,molecular-diagnostics,
Training communication skills in oral healthcare using AI-based conversation simulations

Development and use of an AI-Based conversation simulation (CommAvatar) to train communication in oral healthcare

2026
CommAvatar improves (dental)care by training (future) dental providers communication through realistic, AI-powered patient dialogues
Actief
,mission-i-lifestyle-and-living-environment,
,care,enabling-technologies,
Nanoprobes for Earlier Diagnosis of Alzheimer’s Disease

SiNDA: Silicon Nanoparticles in early Diagnosis of Alzheimer’s Disease

2019
Highly sensitive silicon nanoparticles will be developed to image the brain and diagnose Alzheimer’s disease
Archief
,mission-iv-quality-of-life-for-people-with-dementia,
,cure,imaging,molecular-diagnostics,nanotechnology,
ImmuneHealthSeed for well-balanced immunity

ImmuneHealthSeed: Determining immune profiles of patients with Immune Mediated Inflammatory Diseases for immune-targeting medicines.

2023
Disease-overarching immune profiles to tailor treatment for the million patients with autoimmune diseases
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,
,cure,healthcare,homecare,life-science-and-biotechnologies,molecular-diagnostics,
Improving diagnosis and treatment for patients with peripheral nerve inflammation

Paranodal Antibodies in acute and chronic immune-mediated Neuropathies: improved DIAgnostics for better treatment (PANDIA).

2023
Suboptimal detection of novel auto-antibodies delays adequate treatment of patients with immune-mediated neuropathies: action is required.
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,care,life-science-and-biotechnologies,molecular-diagnostics,
Diagnostic Instrument for Mild Aphasia: digital assessment in neurological patients

Diagnostic Instrument for Mild Aphasia App (DIMA-App): a first step towards digital language assessment in neurological patients

2022
An app to detect mild language disorders in neurological patients will be designed and standardized.
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,
,care,digital-and-information-technologies,enabling-technologies,health-technology-assessment-and-quality-of-life,healthcare,
Sugars to restore neonatal gut health

Mechanisms behind the anti-microbial and barrier-protective activity of non-digestible oligosaccharides against early life intestinal infections OLIGOBIOTICS

2023
Non-digestible oligosaccharides as possible alternative treatment and/or prevention strategy for early life intestinal infections.
Actief
,mission-ii-care-in-the-living-environment,
,cure,pharmacotherapy,specialized-nutrition,
Image

Metallodubi - tools to study ubiquitin metalloprotease activity

2022
Development of advanced reagents for studying and monitoring ubiquitin metalloprotease activity
Actief
,mission-iii-participating-with-a-disease-or-disability,mission-iv-quality-of-life-for-people-with-dementia,
,advanced-materials,bio-pharma,cure,enabling-technologies,molecular-diagnostics,roadmaps,
Logo

Platelet preserving effects of the antifibrinolytic drug Aprotinin as potential contributor to its mode of action as hemostatic agent in cardiac surgery

2021
Aprotinin reduces blood loss in cardiac surgery, but the mode of action is incompletely understood
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,
,bio-pharma,care,molecular-diagnostics,one-health,pharmacotherapy,
Stratification of colon cancer patients for treatment with adjuvant chemotherapy

Stratification of stage II and stage III colon cancer patients for treatment with adjuvant chemotherapy

2019
DNA mutation profiles as colon cancer biomarkers for prognosis and prediction of response to adjuvant chemotherapy
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,
,care,health-technology-assessment-and-quality-of-life,healthcare,life-science-and-biotechnologies,molecular-diagnostics,
Earlier and more accurate detection of birth defects using 3D-ultrasound

An atlas of 3D ultrasound images of human development

2019
Can prenatal 3D-ultrasound screening identify the 60% subtle abnormalities missed by conventional 2D-ultrasound screening?
Archief
,health-technology-assessment-and-quality-of-life,imaging,medical-technology,prevention,
Stressfractuur.nl providing follow-up and feed-back of stress fractures

PROMising platform: digital and save follow-up of stress fractures using patient reported outcome measures (PROMs)

2018
Improve stress fracture treatment and patient-reported-outcomes while simultaneously giving feed-back to participating patients
Archief
,care,health-technology-assessment-and-quality-of-life,healthcare,homecare,
3D-smooth muscle cell assay to identify pharmacotherapy targets for Marfan patients

3D-smooth muscle cell morphology assay to identify personalized aortic pharmacotherapy targets for Marfan Syndrome patients

2019
Marfan patient derived cells will determine personalized pharmacological treatment strategy in the future
Archief
,cure,healthcare,molecular-diagnostics,pharmacotherapy,
The evaluation of gradient scaffolds for osteochondral regeneration

Gradient scaffolds for the treatment of osteochondral defects in the knee – evaluation in an ex vivo osteochondral platform with follow-up by ultra-high field MRI

2020
Ex vivo evaluation of gradient scaffolds for osteochondral regeneration by ultra-high field Magnetic Resonance Imaging
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,
,cure,enabling-technologies,engineering-and-fabrication-technologies,imaging,medical-technology,
Finding and reactivating suppressive immune cells with IgA therapy to attack cancer

TumMyTOF: Tumor MicroEnvironment, Myeloid (suppressor) cells and how to convert them: in situ analysis by CyTOF.

2020
How to turn negative into positive: IgA for cancer
Archief
,bio-pharma,cure,pharmacotherapy,
Magic bullets for the bone marrow

Therapeutic RNA delivery to the bone marrow (TRADBow)

2025
This project will develop targeted nanoparticles to treat childhood leukaemia in the bone marrow
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,cure,nanotechnology,pharmacotherapy,
systemic sclerosis

RESET: Restoring the balance in Systemic sclerosis by Targeting macrophages

2025
We aim to intercept the fibrotic cycle by targeting macrophages as treatment for Systemic Sclerosis
Actief
,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,cure,enabling-technologies,life-science-and-biotechnologies,pharmacotherapy,
IMMUNOFIRE – Lighting the Fire in Immuno-cold Pediatric Brain Tumors

IMMUNOFIRE – Lighting the Fire in Immuno-cold Pediatric Brain Tumors

2023
This project aims to activate the immune system against childhood brain tumors using nanobiologic therapeutics
Actief
,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,cure,life-science-and-biotechnologies,pharmacotherapy,
Non-Alcoholic Fatty Liver Disease – new insights in development and treatment

Characterization of causes that lead to Non-Alcoholic Fatty Liver Disease and the role of the gut and adipose tissue as a target for treatment - ProLiver

2017
New insights and knowledge about the development and treatment of Non-Alcoholic Fatty Liver Disease
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,life-science-and-biotechnologies,pharmacotherapy,prevention,specialized-nutrition,
Ramming the roadblocks; Addressing barriers to translation in bone tissue engineering.

Ramming the roadblocks; Addressing barriers to translation in bone tissue engineering.; ADDBONE

2023
Using paediatric marrow stromal cells to heal large bone defects. Towards the clinic.
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,cure,enabling-technologies,life-science-and-biotechnologies,regenerative-medicine,
Antibody discovery revisited: Generating new tools to tackle emerging viruses

B-cell Puncher Technology: development of a novel antibody discovery pipeline to target emerging viruses (Punch-mAb)

2023
By technological innovation we will advance antibody development to improve resilience against emerging pathogens.
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,enabling-technologies,global-health,life-science-and-biotechnologies,prevention,
2DIAREM

2DIAREM (DIAbetyping for Diabetes type 2 REMission)

2022
2DIAREM will extend and validate the TNO diabetyping algorithms by two minimally invasive methods
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-ii-care-in-the-living-environment,
,digital-and-information-technologies,homecare,medical-technology,molecular-diagnostics,prevention,
Image

Biological Investigation Of Explanted Endobronchial Lung devices (BIO-EXEL) cohort and in vitro studies

2021
Studying cellular interactions with implant materials, to understand and reduce granulation around implanted lung devices
Actief
,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,cure,enabling-technologies,regenerative-medicine,
Lungs

Randomised trial comparing EnVarsus® with PrOgraft®; reducing calcineurin inhibitor related toxicity in LUng TransplantatION patients

2019
Preserving kidney function in lung transplantation patients by changing immunosuppression
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,
,healthcare,medical-technology,molecular-diagnostics,pharmacotherapy,prevention,
Vaccine

An Innovative Intranasal Polyvalent Nanovaccine Applied Towards Coronavirus for Clinical Phase I/II.

2021
This project aims to develop a novel peptide-based, nasally-administered, polyvalent coronavirus nanovaccine to provide effective long-term immunity against SARS-CoV-2 and other viruses.
Actief
,mission-iii-participating-with-a-disease-or-disability,
,cure,enabling-technologies,global-health,life-science-and-biotechnologies,medical-technology,
India Reverses Diabetes type 2

Reversing Diabetes Mellitus type 2 through healthy lifestyle intervention in urban and rural India - a randomized controlled trial

2020
Addressing the crisis of an estimated 74 million diabetes type 2 patients in India
Archief
,mission-i-lifestyle-and-living-environment,
,cure,digital-and-information-technologies,health-technology-assessment-and-quality-of-life,healthcare,specialized-nutrition,
SAFE@home-II study: a telemonitoring platform for hypertensive complications in pregnancy

SAFE@home-II study: a telemonitoring platform combining daily at-home blood pressure measurements with health complaint questionnaires and a reduced number of antenatal hospital visits for women at risk of hypertensive complications in pregnancy

2019
SAFE@home-telemonitoring in pregnancies at risk of hypertensive complications is safe, cost-effective and demonstrated positive user-experience
Archief
,mission-ii-care-in-the-living-environment,
,care,health-technology-assessment-and-quality-of-life,healthcare,homecare,
Image

Cardiovascular precision medicine through autoMated integrATEd diagnostics - CardioMATE

2019
CardioMATE aims to deliver precision medicine by efficiently choosing appropriate diagnostic means for an individual.
Archief
,cure,health-technology-assessment-and-quality-of-life,healthcare,
Towards population screening for kidney disease

Towards population screening for urinary protein loss: an implementation study testing two different approaches

2018
This project aims to evaluate two approaches to screen the general population for urinary protein loss.
Actief
,health-technology-assessment-and-quality-of-life,healthcare,homecare,prevention,
Serological markers for monitoring hepatitis B infections and hepatocellular carcinoma

Serological markers to screen and monitor past or present hepatitis B infection and hepatocellular carcinoma.

2015
Serological hepatitis markers integrated into clinical care: towards clinical response assessment and individualized treatment decisions.
Actief
,care,enabling-technologies,healthcare,molecular-diagnostics,
“Sticky” peptides to fight antimicrobial resistance

PharmAMPs: Pharmaceutical development of antimicrobial peptides for the prevention and treatment of infections against (multi)-drug resistant bacteria.

2015
“Sticky” peptides will prevent that by 2050 antimicrobial resistance will be responsible for about 10 million deaths annually.
Archief
,bio-pharma,global-health,one-health,prevention,
A tiny bone-on-chip model to better understand brittle bones

OImpact - Osteogenesis Imperfecta organ-on-chip Models for Pre-Clinical Testing

2025
Building a tiny bone-on-chip to unlock better treatments for brittle bones
Actief
,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,cure,enabling-technologies,life-science-and-biotechnologies,regenerative-medicine,
Focus-on-Virus

Focus-on-Virus: Picornavirus and HIV infection using a complex gut-brain organoid model

2020
In Focus-on-Virus we study picornaviruses and hiv-infections with the use of complex gut-brain organoid models
Archief
,bio-pharma,cure,global-health,life-science-and-biotechnologies,pharmacotherapy,
A novel therapy for sepsis in the intensive care setting

A phase I trial evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenously administered M6229 in critically ill patients with sepsis - HistoSeps

2020
Novel treatment to reduce organ failure in patients with sepsis appears to be safe
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,
,cure,healthcare,molecular-diagnostics,pharmacotherapy,
sara user

SARA+: Advancing a Socially Assistive care Robot with a focus on Relationships and Acceptance throughout the dementia journey

2025
Enhancing a social robot with multi-sensory features for ethically responsible support throughout all dementia phases.
Actief
,mission-iv-quality-of-life-for-people-with-dementia,
,care,enabling-technologies,engineering-and-fabrication-technologies,health-technology-assessment-and-quality-of-life,healthcare,
PRECISE-R

PReeclamptic Endothelial Conditions: Investigating Specific Endothelial markers for Risk assessment (PRECISE-R)

2025
Towards early detection of preeclampsia: validating ESM-1 and GBP-1 as markers improving outcome and care
Actief
,mission-iii-participating-with-a-disease-or-disability,
,enabling-technologies,global-health,healthcare,life-science-and-biotechnologies,prevention,
Afbeelding

Neurofeedback for resilience and stress prevention (NEUROCENTRE)

2024
Training the brain of emergency workers to improve stress resilience, using occupation-tailored neurofeedback.
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,
,digital-and-information-technologies,healthcare,homecare,imaging,prevention,
Novel Genetic

PredictSMA: advancing SMA diagnosis and prognosis through long read sequencing

2024
Through advanced genetic technology, we aim to predict disease severity and personalize treatment for SMA
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,
,care,enabling-technologies,life-science-and-biotechnologies,molecular-diagnostics,
monitoring

CARE-ON: Cardiovascular Research Opting for New Applications: continuous cardiac risk and lifestyle profiling

2020
Development and evaluation of a digital platform for continuous monitoring of lifestyle behavior and psychological wellbeing
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,
,enabling-technologies,health-technology-assessment-and-quality-of-life,healthcare,life-science-and-biotechnologies,prevention,
CEREBRal vasculature In Stroke – an organ-on-a-chip approach

CEREBRIS: studying the vasculature of the brain in stroke using an organ-on-a-chip approach

2024
Developing a neurovascular unit on-a-chip to study brain vasculature and stroke
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,mission-iv-quality-of-life-for-people-with-dementia,
,bio-pharma,cure,life-science-and-biotechnologies,pharmacotherapy,regenerative-medicine,
https://www.scinus.com/blog/organoid-culture-for-disease-modeling/

Translating Organoid technology towards a Clinical Application

2023
Scalable Liver Organoid Therapy to Address the Global Donor Organ Shortage
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,
,cure,enabling-technologies,engineering-and-fabrication-technologies,life-science-and-biotechnologies,medical-technology,regenerative-medicine,
Multi-factor Lifestyle interventions against cognitive decline (Lifestyle Selfie Study)

Lifestyle Self-Monitoring of Individualized Multiple Risk Factor Management towards Disease Modification of Dementia and other Age-related Diseases (Lifestyle Selfie Study)

2024
Investigating the feasibility of implementing personalized, a self-monitored multi-component lifestyle intervention against cognitive decline through homecare.
Actief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-ii-care-in-the-living-environment,mission-iv-quality-of-life-for-people-with-dementia,
,digital-and-information-technologies,healthcare,homecare,molecular-diagnostics,prevention,
SSc-ILD studie: De rol van ontsteking, fibrose en verkalkingen in de longen bij patiënten met Systemische Sclerose.

Assessing the role of interleukin-6 in local inflammatory and fibroproliferative changes in Systemic Sclerosis related Interstitial Lung Disease: a proof of concept study

2019
A pilot study to explore what is going on in the lungs of patients with scleroderma, to find potentially new disease targets.
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,
,bio-pharma,life-science-and-biotechnologies,molecular-diagnostics,pharmacotherapy,prevention,
The protein HLA-G: a new target for therapy in cancer

HLA-G as a new target for immune checkpoint inhibitors for cancer immunotherapy

2019
The HLA-G protein may be an interesting target for treatment of thousands of cancer patients yearly
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,
,cure,healthcare,imaging,pharmacotherapy,
The heart of epilepsy: innovative guided epilepsy surgery

Vibrations in the heart of epilepsy: innovative guided epilepsy surgery based on electrical high frequency oscillations

2020
New tools to help neurosurgeons find and remove the source of focal epilepsy
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,
,cure,enabling-technologies,imaging,life-science-and-biotechnologies,medical-technology,

Developing an interactive App for high-density symptoms and quality of life mapping

2018
This innovative App will capture day-to-day complaints and impacting factors in various chronic diseases
Archief
,care,health-technology-assessment-and-quality-of-life,homecare,medical-technology,
Natural products as alternatives to antibiotics

NULL

2015
In this project natural herbal compounds will be evaluated for their antibacterial activity.
Archief
,bio-pharma,one-health,prevention,specialized-nutrition,
Extended machine perfusion for the recovery of high-risk donor livers

Extended Machine Perfusion for Organ Reconditioning and Regeneration (EMPORR)

2020
Extended machine perfusion for up to 1 week to repair injured donor livers for transplantation
Archief
,central-mission-5-30-doing-much-more-against-health-inequalities,
,care,cure,enabling-technologies,medical-technology,regenerative-medicine,

Development of a Steep Ramp Test toolkit for easy and standardized assessment of cardiorespiratory fitness

2021
Easy cardiorespiratory fitness assessment: development of a Steep Ramp Test toolkit including norm values
Archief
,mission-i-lifestyle-and-living-environment,mission-ii-care-in-the-living-environment,
,health-technology-assessment-and-quality-of-life,homecare,prevention,
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