Top Sector Life Sciences & Health (LSH) entails a broad scope of disciplines, from pharmaceuticals to medical technology and from healthcare infrastructure to vaccination. To realise its mission – vital citizens in a healthy economy - the Top Sector builds on the strengths of the Dutch LSH sector to address the biggest societal challenges in prevention, cure and care. By funding multidisciplinary public-private partnerships (PPPs) the Top Sector aims to facilitate innovation. Here we give an overview of  a number of funded R&D projects by Top Sector LSH. The page is updated continuously.

Promoting oral health by controlling the microbial ecosystem of the oral cavity

Modulation of the oral ecosystem

Oral health is generally being described as a state of being free from (chronic) oral diseases. In a recent public-private-partnership, members of the current consortium have shown that oral health is much more than that: a complex network of biological processes actively sustains oral health and supports oral resilience. Philips, GlaxoSmithKline, TNO and ACTA Dental Research were able to identify specific salivary ecotypes in healthy individuals, linked to ecological differences and disease risk. Also, they identified biomarkers linked to different individual clinical outcomes, after a stress intervention.

In the current project their main objective is to use their new knowledge to identify strategies to increase oral resilience of (still clinically healthy) individuals. They will modulate the oral ecosystem of individuals and use molecular, biochemical and machine-learning tools to evaluate the effects of ecosystem variation on oral resilience. While doing so, they will also develop new early diagnostic tools and novel approaches to establish the efficacy of oral care products/strategies. Their project is fully focused on prevention and mainlining oral health and functioning.

The different oral ecotypes (risks for different diseases) imply personalized prevention via support/strategies targeted to the individuals’ ecotype.