Projecten | Health Holland

The potential benefit of Spot-scanning Proton Arc Therapy (SPArc) and Beam Modifiers to prevent radiation-induced complications in head and neck cancer

2020

The promise of SPArc technology: preventing complications in head and neck cancer treatment by advancing proton radiotherapy

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,cure,health-technology-assessment-and-quality-of-life,imaging,medical-technology,

GO-IL33: translating asthma genetics into cellular targets to address the IL-33 pathway

2018

Which asthma patients can be treated by targeting IL-33, and how can we monitor their response?

Archief

,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,molecular-diagnostics,pharmacotherapy,

PSO-trial: PSO in Orthognathic Surgery

2020

Improving the accuracy of orthognathic surgery using tailored 3D technology

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,

,care,digital-and-information-technologies,enabling-technologies,imaging,medical-technology,

Extended Machine Perfusion for Organ Reconditioning and Regeneration (EMPORR)

2020

Extended machine perfusion for up to 1 week to repair injured donor livers for transplantation

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,cure,enabling-technologies,medical-technology,regenerative-medicine,

Integrated analysis of genetic and clinical data to improve the stratification of prediabetic and diabetic individuals for more targeted prevention and remission of type 2 diabetes

2020

Whereas healthcare has remained focused on diabetes management, this team looks to change the game

Actief

,mission-iii-participating-with-a-disease-or-disability,

,health-technology-assessment-and-quality-of-life,healthcare,homecare,prevention,

Validation of newly identified targets in AML

2018

The efficacy of newly identified targets in AML in vitro and in vivo will be evaluated

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,bio-pharma,cure,enabling-technologies,molecular-diagnostics,

Allosteric activators of Cystathionine-β-synthase as novel therapeutic agents providing hydrogen sulfide therapy

2020

Unique activating drugs can trigger self-made hydrogen sulfide therapy in high-profile diseases

Actief

,mission-iii-participating-with-a-disease-or-disability,mission-iv-quality-of-life-for-people-with-dementia,

,bio-pharma,cure,pharmacotherapy,

Consequences of maternal diabetes during pregnancy for offspring health

2020

Preclinical studies to investigate metabolic disease risk and -development in offspring born from diabetic pregnancies

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,molecular-diagnostics,prevention,specialized-nutrition,

Stromal tissue-macrophage interactions in pulmonary fibrosis

2019

Exploring novel strategies for reversing tissue imprinting of macrophages in fibrotic lung disease

Actief

,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,pharmacotherapy,regenerative-medicine,

Study to investigate anti-inflammatory effects of Glycopyrronium in asthma

2019

PANTANI study to investigate anti-inflammatory effects of Glycopyrronium in asthma

Actief

,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,healthcare,molecular-diagnostics,pharmacotherapy,prevention,

Frailty Risk Assessment and Improvement in Liver and pancreatic cancer surgery. (FRAIL)

2019

The prehab clinic for a structured way of pre-operative assessment and optimisation of the patient

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,

,healthcare,prevention,specialized-nutrition,

The molecular signature of sepsis induced multi organ failure – unmasking therapeutic targets and diagnostic options in mice and men

2019

Sepsis patients can develop multiple organ failure. Here, new drugable vascular targets will be studied

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,bio-pharma,molecular-diagnostics,prevention,

Platelet preserving effects of the antifibrinolytic drug Aprotinin as potential contributor to its mode of action as hemostatic agent in cardiac surgery

2021

Aprotinin reduces blood loss in cardiac surgery, but the mode of action is incompletely understood

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,bio-pharma,care,molecular-diagnostics,one-health,pharmacotherapy,

Randomised trial comparing EnVarsus® with PrOgraft®; reducing calcineurin inhibitor related toxicity in LUng TransplantatION patients

2019

Preserving kidney function in lung transplantation patients by changing immunosuppression

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,healthcare,medical-technology,molecular-diagnostics,pharmacotherapy,prevention,

Site selective chemotherapeutic releasing vehicles for controlled delivery

2019

A selective approach with use of nanoparticles is investigated to reduce side effects and increase effectiveness of chemotherapy

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,bio-pharma,care,life-science-and-biotechnologies,pharmacotherapy,regenerative-medicine,

Single cell transcriptomics to study spontaneous asthma remission

2018

High-throughput, high resolution single cell transcriptomic profiling of the immune and epithelial cell populations in the airway wall provides insights into the cellular immune pathways

Archief

,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,molecular-diagnostics,prevention,

REconsidering nocturnal non-invasive ventilation in COPD patients with stable hypercAPnic respiraTory failURE (Recapture)

2017

This study investigates if NIV stabilises the lung function via beneficial effects on inflammation and repair pathways

Archief

,mission-iii-participating-with-a-disease-or-disability,

,care,health-technology-assessment-and-quality-of-life,healthcare,homecare,medical-technology,

The Lifelines NEXT is a major study into the course of pregnancy and the health of mother and child

2017

The birth cohort Lifelines NEXT studies the effects of intrinsic and extrinsic determinants on health and disease

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,enabling-technologies,healthcare,life-science-and-biotechnologies,prevention,specialized-nutrition,

Potential of metabolic FGFs in the modulation of hepatocyte function contributing to NAFLD/NASH

2017

Metabolic FGFs and their analogues carry great potential as novel therapeutics to treat metabolic conditions

Archief

,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,pharmacotherapy,specialized-nutrition,

Validation of diagnostic algorithms and identification of novel genes in young patients with unknown primary renal disease (VARIETY)

2018

Uncovering the potential of next-generation sequencing to give patients with unexplained kidney disease a diagnosis

Actief

,mission-iii-participating-with-a-disease-or-disability,

,care,enabling-technologies,healthcare,molecular-diagnostics,

Drug target finding for neuroinflammation in neurodegenerative diseases and ageing, with a focus on Alzheimer’s disease.

2017

Alzheimer’s dementia is highly prevalent in our aging society, and no effective treatment is currently available

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iv-quality-of-life-for-people-with-dementia,

,bio-pharma,molecular-diagnostics,prevention,

Development and applications of enhanced mass spectrometric quantification of peptide hormones

2017

Peptide hormone analysis by LC-MS/MS offers an opportunity to prevent misdiagnosis of endocrine disorders

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,cure,health-technology-assessment-and-quality-of-life,healthcare,molecular-diagnostics,

Consequences of maternal diabetes during pregnancy for maternal and offspring health

2017

Preclinical studies to investigate metabolic disease risk and -development in mothers and offspring exposed to diabetic pregnancies

Archief

,bio-pharma,molecular-diagnostics,prevention,specialized-nutrition,

The ANTIOFLAM Study. Investigating anti-inflammatory effect of Tiotropium in COPD

2018

In this study, they wil investigate whether tiotropium bromide reduces ongoing airway inflammation in patients with COPD

Archief

,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,care,molecular-diagnostics,pharmacotherapy,

Magnesium supplementation and arterial stiffness

2015

Effects of magnesium citrate, magnesium oxide, and magnesium sulfate on arterial stiffness

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,healthcare,prevention,specialized-nutrition,

Development and evaluation of a portal for interdisciplinary communication and collaboration in home rehabilitation after stroke.

2019

A digital portal as a facilitator for interdisciplinary collaboration and communication for efficient personalised home rehabilitation

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,

,cure,digital-and-information-technologies,enabling-technologies,homecare,

Targeted detection and characterisation of chromosomal breakpoints in colorectal cancer

Target:SVs - Targeted detection and functional characterisation of chromosomal breakpoint structural variants in colorectal cancer: advancing towards biomarker assay development

2021

Develop assays detecting DNA structural variants, characterise functional consequences in organoids, translate into cancer biomarkers

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,care,healthcare,life-science-and-biotechnologies,molecular-diagnostics,

AMR-Global: Reducing inappropriate exposure to antibiotics (GLORIA)

2021

GLORIA aims to develop and test interventions to reduce inappropriate antibiotic exposure, particularly in LMIC

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,

,global-health,healthcare,prevention,

ePartners4All: a (personalised and) blended care solution with virtual buddy for child health

2021

A needs assessment, ePartners4All development, and pilot study will be performed in co-creation with end-users

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,

,digital-and-information-technologies,enabling-technologies,healthcare,homecare,prevention,

Towards optimal use of BiTE® antibody constructs nu maximal exploiting the immune system

2015

The usage of bispecific antibodies is a new strategy to combat cancer. The bispecific antibodies, BiTEs in this project, bring the immune cell and the tumor cell together, which leads to an activation of the immune cell. The idea behind this is that the activated immune cell will kill the tumor cell. This technique is already used for hematologic cancer. In this project we will test how BiTE therapy can also be used for solid tumors

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,medical-technology,pharmacotherapy,

‘Esseda’: development, evaluation and implementation of a computer-controlled handrim wheelchair roller ergometer platform.

2017

‘Esseda’ provides an excellent wheelchair exercise testing and monitoring platform for handrim wheelchair performance over the healthy lifespan

Archief

,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,

,enabling-technologies,global-health,healthcare,homecare,prevention,

Holmium radioembolisation as adjuvant treatment to radiofrequency ablation for early stage hepatocellular carcinoma: a dose-finding study

2017

Thermal ablation with adjuvant selective internal radiation therapy in liver cancer patients: a first-in-man study to establish the optimal dose

Archief

,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,cure,healthcare,imaging,life-science-and-biotechnologies,

Slim en effectief afbouwen van zorg in de gemeenschap (Samen Slim Gezond)

2021

Samenwerking tussen burgers, kleine bedrijven, gemeenschapsdiensten en zorgorganisaties voor een gezondere gemeenschap

Archief

,mission-ii-care-in-the-living-environment,

,digital-and-information-technologies,health-technology-assessment-and-quality-of-life,healthcare,homecare,prevention,

The Art of connection: exploring the potentials of smart place making for encouraging social interaction

2021

User-driven smart artworks can evolve our neighbourhoods into places that nurture social health and open- encounter

Actief

,mission-ii-care-in-the-living-environment,

,digital-and-information-technologies,enabling-technologies,health-technology-assessment-and-quality-of-life,healthcare,prevention,

Technology Support for Diabetes: co-design and development of an innovative application

2021

Ondersteuning van mensen met diabetes door de ontwikkeling van een applicatie voor het monitoren van diabetische voeten en andere complicaties.

Archief

,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,digital-and-information-technologies,enabling-technologies,health-technology-assessment-and-quality-of-life,healthcare,homecare,prevention,

Herstelcirkel++ Doorontwikkeling van een sociale innovatie tot een gezondheidscoöperatie voor mensen met diabetes type 2 en (risico op) andere leefstijlaandoeningen

2021

In dit project wordt een gezondheidscoöperatie ontwikkeld die mensen met leefstijlgerelateerde aandoeningen gezamenlijk naar zelfmanagement brengt.

Archief

,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,

,healthcare,homecare,prevention,

MEDIATOR- Microbubble-assisted delivery of microRNA-engineered extracellular vesicles for cardiac applications

2022

New strategy to deliver microRNA molecules in vivo in a spatio/temporal controlled manner

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,mission-iv-quality-of-life-for-people-with-dementia,

,bio-pharma,cure,engineering-and-fabrication-technologies,nanotechnology,pharmacotherapy,regenerative-medicine,

Balance Your Energy (BYE) Fat

2021

More time is needed to develop a sensor for continuous measurement of acetone from the skin

Archief

,mission-iii-participating-with-a-disease-or-disability,

,homecare,medical-technology,molecular-diagnostics,nanotechnology,prevention,

Carnitine supplementation as a therapy to improve insulin sensitivity in Type 2 diabetic patients with low carnitine status

2017

Carnitine supplementation shows promising effects in animals, but effects in humans are largely unknown

Archief

,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,specialized-nutrition,

LIFELINE: eHealth to inform exercise after critical illness

2021

Een bestaande eHealth-toepassing gebruiksvriendelijker en informatiever maken voor beslissingen in de fysiotherapie.

Archief

,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,care,digital-and-information-technologies,enabling-technologies,healthcare,homecare,

Development and validation of a preclinical model for regression of atherosclerosis to understand the underlying disease processes using novel therapeutic options

2016

Development of a preclinical model, in which atherosclerosis regression is established by aggressive cholesterol-lowering treatment

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,life-science-and-biotechnologies,pharmacotherapy,prevention,regenerative-medicine,

Imaging-based metabolomics for discovery of disease-related cellular stress response modulating drugs (IM4DD)

2021

A screening platform for discovery of drugs that modulate cellular stress responses will be developed.

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,

,bio-pharma,enabling-technologies,life-science-and-biotechnologies,pharmacotherapy,prevention,

Elucidation of the structure of DNA polymerase C (PolC) of multidrug resistant bacteria in complex with a novel class of antimicrobials

2021

Inhibitors of PolC are promising antimicrobials, and an understanding of their mode-of-action helps to develop this class of drugs further

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,enabling-technologies,life-science-and-biotechnologies,pharmacotherapy,

Human-Machine Interaction and Pre-Implementation Process of Pacmed Critical at the ICU. HUMAN-IMPACT

2021

This project produces best practices to safely and efficiently implement Artificial Intelligence into clinical practice

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,

,care,digital-and-information-technologies,enabling-technologies,medical-technology,

Real time mUltimodaL and multidisciplinary pERfusion imaging: the RULER project.

2021

The RULER-project aims to aid surgeons by visualising perfusion to prevent catastrophic adverse events

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,care,healthcare,imaging,life-science-and-biotechnologies,medical-technology,

Non-Invasive Photoacoustic Analysis of Cardiovascular disease (NIPAC)

2021

Development of an automated non-invasive photoacoustic spectral imaging surveillance strategy to detect vulnerable atherosclerotic plaques

Actief

,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,health-technology-assessment-and-quality-of-life,healthcare,imaging,life-science-and-biotechnologies,prevention,

An Innovative Intranasal Polyvalent Nanovaccine Applied Towards Coronavirus for Clinical Phase I/II.

2021

This project aims to develop a novel peptide-based, nasally-administered, polyvalent coronavirus nanovaccine to provide effective long-term immunity against SARS-CoV-2 and other viruses.

Actief

,mission-iii-participating-with-a-disease-or-disability,

,cure,enabling-technologies,global-health,life-science-and-biotechnologies,medical-technology,

iPSC-based NMJ-on-a-chip for neuromuscular disease modelling (NOACH, NMJ-On-A-CHip)

2021

A new model to study neuromuscular disorders and treatments on a chip

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,enabling-technologies,life-science-and-biotechnologies,regenerative-medicine,

Validation and development of new dichoptic VR-gamingmethod to treat childhood amblyopia (VAT)

2021

Playing over patching; validating a new treatment for children with amblyopia

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,

,cure,digital-and-information-technologies,homecare,medical-technology,

C4Yourself: Citizen Centred and Controlled COVID-19 data for reuse

2021

In C4Yourself we aimed to realise an ecosystem that enables a centralised overview and real control of a citizens’ own personal (health) data

Archief

,mission-i-lifestyle-and-living-environment,mission-ii-care-in-the-living-environment,

,care,cure,digital-and-information-technologies,enabling-technologies,health-technology-assessment-and-quality-of-life,healthcare,

A Phase I safety and immunogenicity study of ISA104, a therapeutic Synthetic Long Peptides Vaccine to treat Hepatitis B Virus infection; the HEB-PEP study

2021

We aim to clear chronic HBV infection, a tremendous global health burden, with vaccine ISA104

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,global-health,life-science-and-biotechnologies,pharmacotherapy,

Bone metastasis “in a dish”: engineering vascularised bone in vitro to model metastatic breast cancer; BoneMeND

2021

Growing bones in the laboratory to investigate the mechanisms of bone metastasis

Actief

,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,life-science-and-biotechnologies,pharmacotherapy,regenerative-medicine,

Bladder cancer: ready to get killed by therapy?

Ex vivo drug testing for advanced bladder cancer to predict treatment efficacy: EVITA.

2021

Fast and accurate testing to guide the selection of your customised treatment!

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,cure,life-science-and-biotechnologies,medical-technology,molecular-diagnostics,pharmacotherapy,

Seeing is Believing: Extended Reality for Enhancing Personalised Patient Experiences The BELIEF-study

2021

Creating an Extended Reality tool for ‘lifelike’ preoperative visual experiences in facial reconstruction patients

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,care,digital-and-information-technologies,health-technology-assessment-and-quality-of-life,imaging,medical-technology,

Quantification of differential neural control of locomotion

2021

Quantifying the impact of different brain regions on mouse locomotor behavior

Actief

,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,health-technology-assessment-and-quality-of-life,life-science-and-biotechnologies,pharmacotherapy,

A stepwise prediction model integrating high-risk clinicopathological characteristics and genomics to identify advanced cutaneous squamous cell carcinoma (Step-Ident-CSCC Study)

2021

Accurate identification of high risk CSCC patients for developing metastasis by using advanced stepwise methodology

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,enabling-technologies,healthcare,life-science-and-biotechnologies,molecular-diagnostics,prevention,

One-stop breath analyser for better care to vulnerable patients

Decreased deployment of medical resources by applying the one-stop breath analyser in vulnerable patients with chronic diseases

2021

The innovative one-stop breath analyzer decreases deployment of medical resources

Archief

,mission-iii-participating-with-a-disease-or-disability,

,care,global-health,healthcare,molecular-diagnostics,nanotechnology,

CVA-portaal: een innovatieve digitale infrastructuur voor interprofessionele samenwerking en gepersonaliseerde revalidatie thuis.

2021

CVA-portaal: een innovatieve digitale infrastructuur voor interprofessionele samenwerking en gepersonaliseerde revalidatie thuis.

Archief

,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,cure,digital-and-information-technologies,enabling-technologies,homecare,

Het gebruik van technologische toepassingen en hulpmiddelen voor zelfstandig wonen: gericht op de slaap van ouderen met cognitieve stoornissen en daardoor minder zorglast voor mantelzorgers.

2021

Goede nachtrust voor mensen met cognitieve stoornissen, met aandacht voor de belasting van de mantelzorger(s

Archief

,mission-ii-care-in-the-living-environment,mission-iv-quality-of-life-for-people-with-dementia,

,care,digital-and-information-technologies,health-technology-assessment-and-quality-of-life,healthcare,homecare,

PLINT (Preventief Leer- en InnovatieNetwerk Tegen) Ondervoeding

2021

Preventie van ondervoeding bij ouderen door het verbeteren van voorlichting in de thuiszorg, het innoveren van voedselconcepten en het vergroten van bewustwording

Archief

,mission-i-lifestyle-and-living-environment,mission-ii-care-in-the-living-environment,

,homecare,prevention,specialized-nutrition,

Het samen ontwikkelen van digitale communicatieplatforms in ondersteuning en zorg vanuit cliëntenperspectief van mensen die langer thuis willen wonen.

2021

Nieuwe kennis over het gebruik van digitale platforms zal worden gebruikt voor cliëntgerichte ontwikkeling van nieuwe platforms.

Archief

,mission-ii-care-in-the-living-environment,

,care,digital-and-information-technologies,enabling-technologies,health-technology-assessment-and-quality-of-life,healthcare,homecare,prevention,

mtFIT study

2021

This project will validate mtFIT in a prospective study conducted within the Dutch CRC screening program.

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-ii-care-in-the-living-environment,

,enabling-technologies,healthcare,life-science-and-biotechnologies,molecular-diagnostics,prevention,

I-JGZ: Healthy youth through integrated and personalised digital innovations in preventive child health care (JGZ)

2017

Healthy children through data-driven eHealth services in the JGZ

Archief

,mission-ii-care-in-the-living-environment,

,digital-and-information-technologies,enabling-technologies,homecare,prevention,

Ultra-fast and strong MRI for characterising microstructural changes

Ultra-fast and strong gradient diffusion MRI for improved characterization of microstructural changes in Alzheimer’s and Small Vessel Disease leading to dementia

2021

MicroScan will development MRI markers sensitive to tissue compartments that are “off-limits” with conventional MRI

Archief

,mission-ii-care-in-the-living-environment,mission-iv-quality-of-life-for-people-with-dementia,

,enabling-technologies,engineering-and-fabrication-technologies,imaging,prevention,

Prevention of lung disease by finding biomarkers

Precision Medicine for more Oxygen (P4O2)

2020

Understanding early development of lung disease for prediction and prevention

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,health-technology-assessment-and-quality-of-life,molecular-diagnostics,prevention,

Be Positive: A study of the cost-effectiveness of behavioral activation using the NiceDay Smartphone application in psychiatric patients with unipolar depression

2016

Online treatment for depressed patients: does is work and does it cover the costs?

Archief

,mission-ii-care-in-the-living-environment,

,care,enabling-technologies,health-technology-assessment-and-quality-of-life,healthcare,

EnFORCE: Enabling Functional Omics in Routine Clinical Environments by solving computational bottlenecks in mass spectrometry based proteomics

2021

The EnFORCE project develops solutions for real-time processing of mass spectrometry data in clinical laboratories

Archief

,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,care,enabling-technologies,healthcare,life-science-and-biotechnologies,molecular-diagnostics,

IMAGINE

2021

IMAGINE aims to deliver personalised food products into consumers’ daily life by connecting personal data and digital food manufacturing technology, thus allowing consumers to be and/or perform at their best

Archief

,mission-i-lifestyle-and-living-environment,

,bio-pharma,digital-and-information-technologies,enabling-technologies,healthcare,prevention,specialized-nutrition,

Light tissue interactions in ophthalmology

2015

The consortium will investigate how tissue properties are encoded on light signals reflected from the retina

Archief

,mission-iii-participating-with-a-disease-or-disability,

,enabling-technologies,imaging,medical-technology,photonics-and-optical-technologies,prevention,

Ex vivo porcine liver perfusion to study drug pharmacokinetics

Evaluation of Normothermic Machine Perfusion of Porcine Livers as a Novel Preclinical Model to Predict Biliary Clearance and Transporter-mediated Drug-Drug Interactions using Statins

2018

Ex vivo liver perfusion as a model to study hepatic clearance, biliary excretion and DDI

Archief

,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,pharmacotherapy,

Insect derived proteins in sports nutrition: CENTURION

2021

Can insect derived protein in future sports and clinical nutrition products as well as an in products aiming to provide an alternative to the general meat and dairy based products?

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,

,healthcare,prevention,specialized-nutrition,

The multicenter Wavy stress study: Assessing the effect of the ‘Wavy’ application, on stress and burden of disease in women with non-obstructive coronary ischemia caused by vasospasms

2021

Stress management application: ‘Wavy’ may reduce severity and frequency of angina by eliminating stress triggers

Actief

,mission-ii-care-in-the-living-environment,

,care,digital-and-information-technologies,health-technology-assessment-and-quality-of-life,healthcare,homecare,

MOVITA: Wearable technology to optimise prognostic evaluation and rehabilitation of gait behaviour in orthopaedic patients

2021

MOVITA allows for remotely monitoring a patient’s progression in daily-life physical behaviour after knee surgery

Archief

,mission-ii-care-in-the-living-environment,

,care,enabling-technologies,health-technology-assessment-and-quality-of-life,medical-technology,

A stiffness-adjustable ankle-foot-orthosis for time-efficient human-in-the-loop orthosis selection (ADJUST)

2021

Personalising ankle-foot-orthosis stiffness in real-time, to quickly optimise the effectiveness for the individual user

Actief

,mission-iii-participating-with-a-disease-or-disability,mission-iv-quality-of-life-for-people-with-dementia,

,care,enabling-technologies,engineering-and-fabrication-technologies,health-technology-assessment-and-quality-of-life,healthcare,

Patient empowerment using blockchain technology (Blockchain4Patients)

2020

Empower people living with Osteogenesis Imperfecta to own and share their health data using blockchain

Actief

,mission-i-lifestyle-and-living-environment,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,care,digital-and-information-technologies,enabling-technologies,healthcare,homecare,

Precision Orthotics in Stroke, MS and CP – Individualised spastic ankle joint stiffness compensation using Hermes, a novel negative stiffness Ankle-Foot-Orthosis, enabling the remaining muscle capacity to regain control

2021

Redesigning Ankle-Foot-Orthosis Hermes for safe and durable home use to accommodate individual patients’ needs

Actief

,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,care,enabling-technologies,engineering-and-fabrication-technologies,homecare,medical-technology,

Remotely serviced and supported home monitoring of health data during self-preparation for major surgery

2021

Towards a Virtual Connected Care solution for individualised self-managed home-based prehabilitation for an operation

Actief

,mission-ii-care-in-the-living-environment,

,care,digital-and-information-technologies,enabling-technologies,healthcare,homecare,

Porospine: Porous Titanium Cages for Spine Fixation

2020

A new porous titanium cages for spine fixation has been tested for its ability of bone ingrowth

Archief

,mission-iii-participating-with-a-disease-or-disability,

,advanced-materials,cure,health-technology-assessment-and-quality-of-life,life-science-and-biotechnologies,medical-technology,regenerative-medicine,

A garment-integrated artificial intelligence-based sensor system for early detection of stress in people with impaired cognition

2021

Developing a garment-integrated sensor system for stress detection in people with intellectual disabilities and dementia

Archief

,mission-iv-quality-of-life-for-people-with-dementia,

,digital-and-information-technologies,health-technology-assessment-and-quality-of-life,healthcare,homecare,prevention,

Understanding early processes in osteoarthritis: paving the way for novel drugs (HypOA)

2021

This project aims to identify and prevent altered cellular processes in cartilage cause osteoarthritis.

Archief

,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,pharmacotherapy,regenerative-medicine,

Heart failure unraveled with light and sound

Photoacoustic imaging with contrast agents in heart failure

2021

New optical contrast agents will sound the alarm on tissue changes in early heart failure

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-ii-care-in-the-living-environment,

,care,imaging,life-science-and-biotechnologies,medical-technology,molecular-diagnostics,

FERTUS: Generation of cultured red blood cells with enhanced therapeutic potential

2021

FERTUS: novel methods for cost-effective production of functionally enhanced red blood cells for therapeutic use

Archief

,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,kind-of-research,pharmacotherapy,regenerative-medicine,

Instructing immune cells to resolve cancers unresponsive to standard treatment

T-cells act against hard-to-treat cancers (T-ACT)

2020

Development of new immune combination treatments towards cancers of the breast, colon and ovarium

Archief

,mission-ii-care-in-the-living-environment,

,cure,healthcare,pharmacotherapy,

A novel low-risk approach to improve treatment of hematopoietic disorders

Creating a low-risk strategy for rapid and efficient engraftment after hematopoietic stem cell transplantation

2020

We will develop non-toxic protocols for bone marrow conditioning prior to hematopoietic stem cell transplantation

Archief

,mission-iii-participating-with-a-disease-or-disability,

,cure,medical-technology,pharmacotherapy,regenerative-medicine,

Closing the gap between in-vitro and in-vivo blood flow quantification using vector flow imaging in stents promoting swirling flow

2021

How blood flow and stents interact, helical stents the future in peripheral artery stenting

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,cure,digital-and-information-technologies,global-health,imaging,medical-technology,

Design of effective synthetic long peptide (SLP)-based therapeutic capable of inducing an effective immune response against hepatitis B virus-infected cells by avoiding immune tolerance and viral resistance

2016

SLP based immunotherapy may offer functional cure for millions of people worldwide suffering from chronic hepatitis B

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,global-health,life-science-and-biotechnologies,pharmacotherapy,

Making preoperative anesthesiological screening future-proof

Preoperative anaesthesiological screening revised: breaking with the face‐to‐face dogma Acronym: DIGICA (DIGital Informed Consent in Anaesthesia)

2020

A patient-centred tailor-made future-proof preoperative anaesthesiological screening platform to facilitate care in the patient’s home-environment

Archief

,mission-ii-care-in-the-living-environment,

,care,digital-and-information-technologies,health-technology-assessment-and-quality-of-life,healthcare,homecare,medical-technology,

NANOCAST: Nanoparticles for Cas9 targeting in blood stem cells

2020

NANOCAST will develop nanoparticles for delivery of genome editing components to blood stem cells

Archief

,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,pharmacotherapy,

Speeding up MRI with AI: fast MRI applications in prostate cancer

2021

Investigating speeding up MRI in prostate cancer with innovative AI techniques

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,cure,healthcare,imaging,life-science-and-biotechnologies,

Intestinal Yeasts associated with Inflammatory Bowel Disease and Irritable Bowel Syndrome (YBD/S)

2021

YBD/S studies the impact of fecal yeast diversity on bowel inflammation and irritable bowel syndrome

Archief

,mission-iii-participating-with-a-disease-or-disability,

,healthcare,life-science-and-biotechnologies,molecular-diagnostics,prevention,specialized-nutrition,

Episign: high frequency oscillations based epilepsy surgery

2016

Technical innovation can guide the neurosurgeon to the source of focal epilepsy and enable cure

Archief

,mission-iii-participating-with-a-disease-or-disability,

,cure,enabling-technologies,life-science-and-biotechnologies,medical-technology,

An hiPSC-based fluorescent reporter imaging platform for drug discovery to combat polycystic kidney disease, KIDNEY3D

2021

Development of CRISPR-based stem cell reporters for 3D organoid models of polycystic kidney disease for imaging-based drug screening

Archief

,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,imaging,life-science-and-biotechnologies,regenerative-medicine,

A Personalised Medicine Approach for Alzheimer’s Disease (ABOARD)

2021

Stopping Alzheimer’s before it starts

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iv-quality-of-life-for-people-with-dementia,

,digital-and-information-technologies,enabling-technologies,healthcare,molecular-diagnostics,prevention,

Towards implementation of liquid biopsy cell-free circulating tumour DNA as prognostic biomarker for stage III colon cancer patients: the PROVENC3 study

2019

Can liquid biopsy ctDNA analysis guide decisions who (not) to treat with adjuvant chemotherapy?

Actief

,mission-iii-participating-with-a-disease-or-disability,

,care,healthcare,molecular-diagnostics,

Advanced analysis of primary fixation of total knee arthroplasty components

2021

This project investigates mechanical fixation of total knee arthroplasty implants in the human body

Archief

,mission-iii-participating-with-a-disease-or-disability,

,care,digital-and-information-technologies,health-technology-assessment-and-quality-of-life,healthcare,imaging,medical-technology,

The development of a rapid, web-based calculator for the screening of periodontitis in a medical care setting

2019

A simple and rapid web-tool to screen for gum disease in the medical setting

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,

,enabling-technologies,health-technology-assessment-and-quality-of-life,life-science-and-biotechnologies,prevention,

CARMEN: Using continuous imaging to optimise the differentiation of induced pluripotent stem cells for personalised medicine applications

2020

Paving the way for patient-specific diagnostics and treatment selection using stem cell derivatives

Archief

,bio-pharma,cure,enabling-technologies,life-science-and-biotechnologies,regenerative-medicine,

Translation of high-throughput genetics from inbred dogs to identify mutations involved in complex genetic diseases in humans

2021

Genetic studies in inbred dogs will be used to elucidate complex genetic disorders in humans

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,care,enabling-technologies,life-science-and-biotechnologies,medical-technology,one-health,

Theyeasts.org, the on-line tool to IDentify Clinically relevant Yeasts (IDCY)

2018

Theyeasts.org will help users around the globe to identify yeast isolates rapidly and correctly

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,global-health,healthcare,life-science-and-biotechnologies,molecular-diagnostics,prevention,

ADMIR: Systematic assessment of microRNA-132 supplementation to treat Alzheimer’s disease

2021

This project tests the therapeutic potential and safety of microRNA-132 supplementation as therapeutic strategy in Alzheimer’s disease.

Archief

,mission-iv-quality-of-life-for-people-with-dementia,

,bio-pharma,cure,global-health,life-science-and-biotechnologies,pharmacotherapy,