Projecten | Health Holland

IMAGINE: Innovations for the manufacturing and marketing of fully personalized food products

2021

Improve health or performance by making personalized foods based on digital food manufacturing technology

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,

,care,digital-and-information-technologies,health-technology-assessment-and-quality-of-life,healthcare,specialized-nutrition,

How does obesity lead to dementia: a role for inflammation?

The adipose tissue – brain axis as an inflammatory link between obesity and Alzheimer’s Disease

2023

AT-BRAIN will investigate how obesity increases Alzheimer’s Disease risk

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iv-quality-of-life-for-people-with-dementia,

,healthcare,life-science-and-biotechnologies,molecular-diagnostics,pharmacotherapy,prevention,

Early detection of work-related health risks (RISK@WORK)

2023

RISK@WORK will develop a mass spectrometric-based workflow to identify risks from exposures to hazardous chemicals

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,

,chemical-technologies,enabling-technologies,healthcare,molecular-diagnostics,prevention,

Development of a robust method to simultaneously detect ribosome profiles and transfer RNAs in individual fixed cells

2023

Development of a novel method to determine the location of ribosomes along transcripts in single fixed cells

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,missie-v-better-protection-against-health-threats,

,enabling-technologies,life-science-and-biotechnologies,medical-technology,molecular-diagnostics,prevention,

Home Monitoring & E-health for Inflammatory Bowel Disease

2023

This project aims to detect and predict flare-ups and help patients monitor Inflammatory Bowel Disease at home using smart technologies.

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,digital-and-information-technologies,healthcare,homecare,prevention,

Proof of concept for a data driven approach for prevention of disease

A digital, data driven approach for differentiated prevention (Acronym: D4P)

2023

A unique data approach enabling tailored prevention and care

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,

,digital-and-information-technologies,enabling-technologies,health-technology-assessment-and-quality-of-life,healthcare,prevention,

Immune events at the blood-brain barrier

IMM-BBB: development of tools to study immunological changes of the blood-brain barrier in support for neurological diseases such as multiple sclerosis and Alzheimer’s disease

2023

Advanced cellular and organ-on-chip models to improve of study multiple sclerosis and Alzheimer’s disease

Actief

,mission-iii-participating-with-a-disease-or-disability,mission-iv-quality-of-life-for-people-with-dementia,

,bio-pharma,cure,enabling-technologies,health-technology-assessment-and-quality-of-life,life-science-and-biotechnologies,

Precision nutrition based on metabolic subgroups leads to clinically relevant further improvements in insulin sensitivity and cardiometabolic health

Precision Nutrition in the prevention of chronic metabolic diseases

2023

Precision nutrition based on metabolic subgroups leads to clinically relevant further improvements in insulin sensitivity and cardiometabolic health

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,

,healthcare,life-science-and-biotechnologies,one-health,prevention,specialized-nutrition,

Abnormal protein degradation in familial and sporadic Parkinson’s disease

Abnormal autophagy-lysosomal pathways underlying orphan and common Parkinson’s disease: towards disease-modifying therapeutic strategies. Acronym: ALP-disease

2019

Exploring regulation of protein degradation mechanisms for the development of disease-modifying pharmacotherapy in Parkinson’s disease.

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,molecular-diagnostics,pharmacotherapy,

Investigating the drivers in the individual aggressive tumour biology of pancreatic cancer patients

Dissecting Drivers of poor prognosis to Improve and Tailor the Treatment of Pancreatic Cancer

2023

Deepening pancreatic cancer knowledge aiming to unveil key insights on tumour biology, guiding prognosis and treatment effectiveness.

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,care,enabling-technologies,healthcare,molecular-diagnostics,

Better diagnosis/prognosis of preschool asthma by an innovative breath test

A point-of-care breath test for better prognosis and less health care costs of preschool children with asthma-like symptoms

2018

A breath test is able to diagnose asthma at an early age.

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,care,enabling-technologies,life-science-and-biotechnologies,medical-technology,molecular-diagnostics,

Diagnosis of Acute Respiratory disTress Syndrome by exhaled breath (DARTS)

Bedside exhaled breath octane measurements for the diagnosis and monitoring of treatment response in patients with acute respiratory distress syndrome

2017

In this project we developed a breath test for acute respiratory distress syndrome

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,chemical-technologies,cure,medical-technology,molecular-diagnostics,

Track-AMR: Track antimicrobial resistance genes by metagenomics in enteric pathogens

Drivers of antimicrobial resistance in enteric pathogens: proximity-ligation metagenomics to track antimicrobial resistance genes across microbes in space and time. (Track-AMR)

2023

Hi-C sequencing to understand how enteropathogens acquire antimicrobial resistance

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,missie-v-better-protection-against-health-threats,mission-i-lifestyle-and-living-environment,

,global-health,healthcare,life-science-and-biotechnologies,one-health,prevention,

A prosthesis to restore vision in the blind

2023

The project POSITIONED develops a new probe to restore vision for blind people

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,care,homecare,life-science-and-biotechnologies,medical-technology,regenerative-medicine,

IMMUNOFIRE – Lighting the Fire in Immuno-cold Pediatric Brain Tumors

2023

This project aims to activate the immune system against childhood brain tumors using nanobiologic therapeutics

Actief

,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,life-science-and-biotechnologies,pharmacotherapy,

FUMES – Focused ultrasound-mediated drug delivery high-tech engineering solutions

2023

This project aims to optimize preclinical drug pharmacokinetics and focused ultrasound-mediated drug delivery in neuro-oncology

Actief

,mission-iii-participating-with-a-disease-or-disability,

,cure,engineering-and-fabrication-technologies,medical-technology,pharmacotherapy,

Mixed Reality Holography in Brain Tumor Surgery in Children

FUrther developmenT of holography to improve tUmor Resection in childrEn in 3 Dimensions. FUTURE-3D

2023

Mixed Reality Holography in Brain Tumor Surgery in Children will be developed and investigated

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,cure,digital-and-information-technologies,health-technology-assessment-and-quality-of-life,healthcare,medical-technology,

Innovative Surgical techniques for Eyes with Advanced glaucoma (I-SEA)

2023

Revolutionizing glaucoma treatment: A new implant offers hope, lowers costs, and saves sight

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,care,cure,engineering-and-fabrication-technologies,health-technology-assessment-and-quality-of-life,homecare,

https://www.scinus.com/blog/organoid-culture-for-disease-modeling/

Translating Organoid technology towards a Clinical Application

2023

Scalable Liver Organoid Therapy to Address the Global Donor Organ Shortage

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,

,cure,enabling-technologies,engineering-and-fabrication-technologies,life-science-and-biotechnologies,medical-technology,regenerative-medicine,

Experiences and Needs of people living with Prolonged Incurable Cancer

Living with the shadow of death: Participation in society, experiences, wishes and needs of people living with prolonged incurable cancer

2022

‘It’s amazing that I’m alive, it’s also amazingly difficult’

Archief

,mission-iii-participating-with-a-disease-or-disability,

,care,digital-and-information-technologies,health-technology-assessment-and-quality-of-life,healthcare,homecare,

Development and evaluation of a technology-based tool to support IBS patients towards a healthy diet

2023

This interdisciplinary project combines expertise in IBS, diet, and technology to develop a support tool with and for IBS patients

Actief

,care,cure,digital-and-information-technologies,health-technology-assessment-and-quality-of-life,medical-technology,specialized-nutrition,

Dendritic Cell Targeting for Resetting the Immune Balance

Resetting the immune balance in patients with autoimmunity, chronic inflammatory diseases, and cancer by targeting dendritic cells with particulated antigen and adjuvant

2018

Dendritic cell-modulating therapeutics for disease-specific immunity or tolerance to restore the immune balance

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,pharmacotherapy,roadmaps,

4. Target to B! - Towards patient-tailored immunotherapy to effectively treat B-cell associated disease

2018

This public-private project was aimed to understand B-cell disease by disease-overarching comparisons of different antibody-mediated diseases, analysis of antibody and B-cell receptor specifics, and the variable response to immunotherapy.

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,missie-v-better-protection-against-health-threats,mission-iii-participating-with-a-disease-or-disability,

,care,enabling-technologies,healthcare,life-science-and-biotechnologies,molecular-diagnostics,prevention,

ImmuneHealthSeed for well-balanced immunity

ImmuneHealthSeed: Determining immune profiles of patients with Immune Mediated Inflammatory Diseases for immune-targeting medicines.

2023

Disease-overarching immune profiles to tailor treatment for the million patients with autoimmune diseases

Actief

,cure,healthcare,homecare,life-science-and-biotechnologies,molecular-diagnostics,

Non-Alcoholic Fatty Liver Disease – new insights in development and treatment

Characterization of causes that lead to Non-Alcoholic Fatty Liver Disease and the role of the gut and adipose tissue as a target for treatment - ProLiver

2017

New insights and knowledge about the development and treatment of Non-Alcoholic Fatty Liver Disease

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,life-science-and-biotechnologies,pharmacotherapy,prevention,specialized-nutrition,

Fit for the future: the Vital Craftmanship Action Program

Vital Craftmanship Action Program: sustainable health and employability for practically trained technicians

2018

Supporting organizations to reverse mental retirement and to restore the fit between employees and work

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,

,health-technology-assessment-and-quality-of-life,healthcare,homecare,prevention,

Verbeterde immuun therapie voor aggressieve borst kanker

Next-generation T-cell therapy for novel solid cancer target

2024

We apply a novel genetic approach to improve potency and durability of adoptive T-cell therapy.

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,life-science-and-biotechnologies,pharmacotherapy,

Quantified (self)management for people with post-cancer fatigue

Quantified (self)management for people with cancer related fatigue (project QUANT)

2024

The application of digital biomarkers from real-world data to better manage cancer related fatigue

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,care,digital-and-information-technologies,health-technology-assessment-and-quality-of-life,healthcare,homecare,

Multi-factor Lifestyle interventions against cognitive decline (Lifestyle Selfie Study)

Lifestyle Self-Monitoring of Individualized Multiple Risk Factor Management towards Disease Modification of Dementia and other Age-related Diseases (Lifestyle Selfie Study)

2024

Investigating the feasibility of implementing personalized, a self-monitored multi-component lifestyle intervention against cognitive decline through homecare.

Actief

,digital-and-information-technologies,healthcare,homecare,molecular-diagnostics,prevention,

Animal-free heparin production and characterisation

Alternative, animal-free heparin production and product characterisation

2023

Introduction of animal-free heparin for sustainable access to an essential blood thinner

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,enabling-technologies,global-health,life-science-and-biotechnologies,

Development of a test for the early detection of liver cancer

The LEGACY project will develop a cross-etioLogy Early-staGe hepAtocellular Carcinoma assay based on plasma derived protein biomarkers

2024

The LEGACY project will develop a cross-etioLogy Early-staGe hepAtocellular Carcinoma assay based on plasma derived protein biomarkers

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-ii-care-in-the-living-environment,

,healthcare,homecare,life-science-and-biotechnologies,molecular-diagnostics,prevention,

Measuring brain delivery of novel medication for Alzheimer’s Disease

Across the blood brain barrier: measuring brain delivery of monoclonal antibodies with 89Zirconium-immuno-PET. Acronym: Brain Immuno-PET

2024

This proof-of-concept study develops the technique to quantify brain delivery and distribution of monoclonal antibodies.

Actief

,mission-iv-quality-of-life-for-people-with-dementia,

,cure,engineering-and-fabrication-technologies,healthcare,imaging,pharmacotherapy,

additiVe manufacturInG mechanobIoLogy spinAl fusioN Clinical excellence (VIGILANCE)

Application of additive manufacturing, mechanobiology and osseointegrative coatings in spinal cage design to improve spinal fusion results.

2023

Application of additive manufacturing, mechanobiology and osseointegrative coatings in spinal cage design to improve spinal fusion results.

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,

,advanced-materials,cure,regenerative-medicine,

Maximal learning from experimental vaccination to treat chronic Hepatitis B

Maximal knowledge exploitation from our first-in human therapeutic vaccine trial (HEB-PEP) to treat chronic hepatitis B (MAX-HEB-PEP)

2023

Optimal monitoring of the effect of ISA104, an experimental therapeutic vaccine for chronic hepatitis B virus infection.

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,global-health,life-science-and-biotechnologies,pharmacotherapy,

Improving diagnosis and treatment for patients with peripheral nerve inflammation

Paranodal Antibodies in acute and chronic immune-mediated Neuropathies: improved DIAgnostics for better treatment (PANDIA).

2023

Suboptimal detection of novel auto-antibodies delays adequate treatment of patients with immune-mediated neuropathies: action is required.

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,care,life-science-and-biotechnologies,molecular-diagnostics,

Turbine-Based Insufflator for improved surgery

Bringing the Turbine-Based Insufflator to the Clinic: Improving Surgical Performance and Outcome through Enhanced Ventilation and Personalized Insufflation Pressure

2023

Optimizing surgical conditions with a turbine-based insufflator

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,cure,enabling-technologies,homecare,medical-technology,

Looking at the effectivity of antibiotics in a new way

New diagnostic and therapeutic strategies to fight bacteria in patients with difficult to treat infections. Acronym: At the Roots

2023

Application of new technology on determining effective antibiotic treatment of difficult to treat bacteria

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,cure,global-health,healthcare,life-science-and-biotechnologies,pharmacotherapy,

Ramming the roadblocks; Addressing barriers to translation in bone tissue engineering.; ADDBONE

2023

Using paediatric marrow stromal cells to heal large bone defects. Towards the clinic.

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,enabling-technologies,life-science-and-biotechnologies,regenerative-medicine,

Antibody discovery revisited: Generating new tools to tackle emerging viruses

B-cell Puncher Technology: development of a novel antibody discovery pipeline to target emerging viruses (Punch-mAb)

2023

By technological innovation we will advance antibody development to improve resilience against emerging pathogens.

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,enabling-technologies,global-health,life-science-and-biotechnologies,prevention,

A natural RNA therapeutics delivery system for cancer treatment

NEXT - Nucleic acid delivery by bioengineered extracellular vesicles for prostate cancer treatment

2023

This project will develop bioengineered extracellular vesicles as a proof of concept novel modality to deliver therapeutic anticancer nucleic acids. We will optimize scalable bioreactor production and establish their bioactivity in vitro. Efficacy and biodistribution will be evaluated in preclinical animal models of prostate cancer.

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,mission-iv-quality-of-life-for-people-with-dementia,

,bio-pharma,cure,enabling-technologies,life-science-and-biotechnologies,pharmacotherapy,

Guiding brain surgery with four-dimensional ultrasound images

Intraoperative four-dimensional functional ultrasound brain imaging (4DBrain)

2023

Four-dimensional functional ultrasound of the brain will help neurosurgeon to operate precise and safe.

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,mission-iv-quality-of-life-for-people-with-dementia,

,cure,engineering-and-fabrication-technologies,health-technology-assessment-and-quality-of-life,imaging,medical-technology,

What is the true burden of atrial fibrillation?

Unravelling True buRden of atrIal fibrillation across the whole spectrUm; froM asymPtomatic pHase to critical disease (TRIUMPH)

2022

TRIUMPH develops a comprehensive, clinically and pathophysiologically meaningful AF measure to guide personalized AF management.

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,digital-and-information-technologies,enabling-technologies,homecare,life-science-and-biotechnologies,prevention,

Diagnostic Instrument for Mild Aphasia: digital assessment in neurological patients

Diagnostic Instrument for Mild Aphasia App (DIMA-App): a first step towards digital language assessment in neurological patients

2022

An app to detect mild language disorders in neurological patients will be designed and standardized.

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,care,digital-and-information-technologies,enabling-technologies,health-technology-assessment-and-quality-of-life,healthcare,

Targeting the “sugar receptor” Siglec-10 for immune regulation

Targeting the glyco-immune checkpoint receptor Siglec-10 for immune regulation

2023

Targeting the glyco-immune checkpoint receptor Siglec-10 for immune modulation in cancer and autoimmune diseases

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,enabling-technologies,life-science-and-biotechnologies,pharmacotherapy,

Personalized mass spectrometry to improve diagnostics of hematological cancers

PRIME-TIME: Personalized mass spectrometry as novel standard for minimal invasive M-protein diagnostics

2023

PRIME-TIME develops personalized minimal invasive diagnostics to predict, prevent and monitor disease-activity of hematological cancers.

Actief

,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,care,enabling-technologies,healthcare,life-science-and-biotechnologies,molecular-diagnostics,

Inhibiting the spread of mosquito-transmitted viruses

PANTIVIRAL: Pandemic preparedness through the development of broadly-acting antiviral drugs

2023

Radboudumc and TropIQ Health Sciences collaborate to find new ways to stop the spread of mosquito-borne viruses

Archief

,missie-v-better-protection-against-health-threats,mission-i-lifestyle-and-living-environment,

,bio-pharma,global-health,life-science-and-biotechnologies,one-health,prevention,

Anti-fibrotic photodynamic therapy to relieve scleroderma – part 2 (APOLLO-2)

2023

APOLLO-2 will deliver an innovative therapy to fight fibroblast-driven diseases like scleroderma.

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,care,imaging,life-science-and-biotechnologies,pharmacotherapy,

Predict and Prevent Emerging Pathogen Threats

2023

The integration of pan-genomics, population dynamics and clinical outcomes to elucidate emerging pathogen threats using machine learning.

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,

,enabling-technologies,healthcare,life-science-and-biotechnologies,one-health,prevention,

Following cancer cells spreading to bone in small microfluidic devices

Bone Metastasis chip with micro-physiological circulation for cancer profiling (OSCAR)

2023

A bone-metastasis-chip (OSCAR) with a recirculation system (CRIS) is developed to recapitulate the passage of cancer cells from the blood to bone in order to understand what mechanisms support bone metastasis formation and can ultimately be exploited for therapy

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,enabling-technologies,life-science-and-biotechnologies,molecular-diagnostics,

Patient outcome oriented care: an integral approach for patients with osteoarthritis

Development and validation of an osteoarthritis module for the Assessment of Burden of Chronic Conditions (ABCC)-tool

2023

Using the ABCC-tool for patients with osteoarthritis; a new approach to guide care and selfmanagement

Actief

,care,digital-and-information-technologies,healthcare,homecare,prevention,

Development of artificial intelligence driven F-18-Fluoride PET/CT analysis of bone and joint pathology in spondyloarthritis and beyond

Using artificial intelligence to train computers to analyse PET/CT scans of bone and joint abnormalities in spondyloarthritis.

2023

Development of automated PET/CT scan analysis for fast and accurate diagnosis and monitoring of spondyloarthritis

Actief

,mission-iii-participating-with-a-disease-or-disability,

,care,digital-and-information-technologies,imaging,medical-technology,molecular-diagnostics,

Proof of concept for peptide-based treatment against osteoarthritis

PEP DMOAD; Proof of concept for a peptide-based disease-modifying osteoarthritis drug candidate

2022

The next step in development and proof of concept for a peptide-based disease-modifying osteoarthritis drug candidate

Actief

,bio-pharma,cure,pharmacotherapy,regenerative-medicine,

Mechanisms behind the anti-microbial and barrier-protective activity of non-digestible oligosaccharides against early life intestinal infections OLIGOBIOTICS

2023

Non-digestible oligosaccharides as possible alternative treatment and/or prevention strategy for early life intestinal infections.

Actief

,mission-ii-care-in-the-living-environment,

,cure,pharmacotherapy,specialized-nutrition,

Immediate pressure-guided multivessel revascularisation after an acute myocardial infarction

Instantaneous wave-free ratio guided multivessel revascularisation during percutaneous coronary intervention for acute myocardial infarction

2017

Radboudumc cardiologists investigate the optimal treatment for myocardial infarction patients with multiple coronary narrowings

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,care,digital-and-information-technologies,health-technology-assessment-and-quality-of-life,healthcare,imaging,medical-technology,

Improved drugs by selecting safer drug targets with TargetTri

TargetTri: an integrative platform to analyse safety aspects and triage drug targets

2018

Knowing everything about your drug target is imperative for the efficient development of innovative drugs

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,

,bio-pharma,cure,enabling-technologies,life-science-and-biotechnologies,pharmacotherapy,

MOS-ROSETTES: Inhibiting the formation of T-cell rosettes in Hodgkin lymphoma using MicroOrganoSpheres to develop more targeted less toxic treatment

2023

Towards more targeted and less toxic treatment of Hodgkin lymphoma by studying patient derived MicroOrganoSpheres

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,care,cure,healthcare,life-science-and-biotechnologies,molecular-diagnostics,pharmacotherapy,

The Netherlands Network for Difficult-To-Treat Depression: Towards a better positioning of novel pharmacological treatment

2023

State of the art research and data science to improve clinical care for depression

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,cure,digital-and-information-technologies,healthcare,molecular-diagnostics,pharmacotherapy,

Scan2Go: Autonomous MRI for large scale diagnostics of brain integrity

2023

Perception study of low-cost automatic self-scan MRI with article intelligence that translates images to diagnose

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,care,enabling-technologies,engineering-and-fabrication-technologies,imaging,medical-technology,

Automated Organoid-based screening assay for Diagnostic purposes

2021

Automated miniaturisation of a colorectal cancer organoid screening assay for testing standard-of-care drugs

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,cure,enabling-technologies,health-technology-assessment-and-quality-of-life,life-science-and-biotechnologies,medical-technology,

ADVOCATE: Advanced complexity in human derived organoid models for virology

2023

This project will understand virus-induced paralysis using a stem cell-based model of the neuromuscular junction

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,enabling-technologies,life-science-and-biotechnologies,pharmacotherapy,

Periodic use of a fasting-mimicking diet in type 2 diabetes

Integrating a fasting-mimicking diet program in regular primary care promotes regression of type 2 diabetes; results of a 12- month randomised, controlled, assessor-blinded study

2017

Periodic use of a fasting-mimicking diet as an adjunct to regular care improves glycemic management in type 2 diabetes patients

Actief

,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,

,cure,healthcare,specialized-nutrition,

High throughput Screening to identify novel molecules enhancing the activity of the cardio-protective enzyme 5- oxoprolinase (OPLAH) for the treatment of Heart Failure

2018

We generated recombinant 5-oxoprolinase and developed a screening platform to identify new compounds to treat heart failure

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,pharmacotherapy,

Rapid SARS-CoV-2 detection and variant characterization using mass spectrometry coupled to AI predictions of variants of high risk: Staying ahead of the virus (STAYAHEAD)

2022

We predict and detect emerging high-risk variants of SARS-CoV-2 using mass spectrometry and machine learning

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,chemical-technologies,enabling-technologies,healthcare,prevention,

NeurOsTImulation for clOsed-loop brain computer-interface coNtrol (NOTION)

2022

Natural feedback for improved training and performance of a communication-BCI for people with locked-in syndrome.

Actief

,mission-ii-care-in-the-living-environment,

,care,digital-and-information-technologies,homecare,life-science-and-biotechnologies,medical-technology,

HEalth ReseArch - Cancer Living labs - setting up an Ecosystem of trust (Secure and Sovereign)

2022

To combine data in a secure way from multiple sources for lung and ovarium cancer research

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,care,digital-and-information-technologies,enabling-technologies,healthcare,pharmacotherapy,

Muscle exercise in a muscle-on-a-chip model

Noninvasive analysis of muscle-on-a-chip: increased throughput, exercise modules, and application to muscle disease

2023

Human healthy and diseased miniature muscles will be grown and exercised on a chip

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,enabling-technologies,life-science-and-biotechnologies,prevention,regenerative-medicine,

REPIC: RSV Entry Pathway in Human Ciliated Airway Cells

2022

The search for roadblocks to viral infection of the human lung

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,bio-pharma,life-science-and-biotechnologies,one-health,pharmacotherapy,prevention,

2DIAREM (DIAbetyping for Diabetes type 2 REMission)

2022

2DIAREM will extend and validate the TNO diabetyping algorithms by two minimally invasive methods

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-ii-care-in-the-living-environment,

,digital-and-information-technologies,homecare,medical-technology,molecular-diagnostics,prevention,

DIGNIC: digital personalised aftercare following an admission in the intensive care unit development of a Personal Healthcare Environment

2022

This project will develop a digital personalised aftercare programme for patients and relatives after ICU admission, on-demand and 24/7 available

Actief

,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,care,digital-and-information-technologies,health-technology-assessment-and-quality-of-life,healthcare,homecare,

PROTAI - Artificial intelligence for protein stabilisation in vaccine design

2022

We construct an AI that identifies unstable regions in protein structures for improving vaccine design

Actief

,mission-ii-care-in-the-living-environment,

,bio-pharma,digital-and-information-technologies,global-health,prevention,specialized-nutrition,

Development of a cost-effective large-scale culturing platform to derive hematopoietic cells from human induced pluripotent stem cells (iPSCs)

2023

Translation of the enormous potential of induced pluripotent stem cells (iPSCs) in regenerative medicine requires upscaling and defined cell culture conditions allowing cost-effective production of cells.

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,enabling-technologies,life-science-and-biotechnologies,regenerative-medicine,

Vital@Work: an evidence-based intervention programme for prevention, treatment and reintegration of mental health complaints at work, tailored to specific organisational needs and contextual factors

2022

Vital@Work supports employers and employees to prevent and treat work stress by tailored interventions.

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,health-technology-assessment-and-quality-of-life,healthcare,homecare,prevention,

Remotely controlled T cell therapies for cancer, RemoTe

2022

Development of next generation cell therapies armored to controllably induce local inflammation to increase anti-tumor activity

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,bio-pharma,cure,enabling-technologies,life-science-and-biotechnologies,pharmacotherapy,

Engineering T-cells with nucleic acids

2023

In this project we engineer immune cells with nanoparticles containing DNA to recognize and attack tumor cells

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,bio-pharma,cure,enabling-technologies,life-science-and-biotechnologies,pharmacotherapy,

Using sustainable omega-3 rich oils to improve gut-brain health

2022

It takes guts to BBB: Using sustainable omega-3 rich oils to improve gut-brain health

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,healthcare,one-health,prevention,specialized-nutrition,

Developing microRNA based therapy for Amyotrophic lateral sclerosis

Identification of a new microRNA as a diagnostic and therapeutic target for Amyotrophic lateral sclerosis. Targeted expression of AAV sponge vectors to normalize aberrant microRNA levels in Motor Neurons and Microglial cells (IMiDiaTALS)

2023

The IMiDiaTALS project is to identify novel treatment strategy to treat Amyotrophic lateral sclerosis

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,life-science-and-biotechnologies,molecular-diagnostics,pharmacotherapy,prevention,

Combining laser and immunotherapy for Uveal Melanoma to Save Lifes

Combining a new laser-guided treatment for uveal melanoma with checkpoint inhibitors to prevent Loss of Vision and Save Lifes : Laserlmmune

2019

Combining laser treatment of intraocular tumors with immunotherapy may prevent metastases by stimulating immune responses.

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,cure,enabling-technologies,healthcare,life-science-and-biotechnologies,pharmacotherapy,

Novel diagnostics to match donors and recipients for organ transplantation

Exploring novel methods for robust multiplexed HLA-typing

2020

New genetic methods to improve HLA-typing and match donors and recipients for organ transplantation.

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,cure,life-science-and-biotechnologies,medical-technology,molecular-diagnostics,

CARDIOIDS: Comparative testing of human cardiac organoids with animal models of inherited heart disease

2022

In the current project, a university and a biotechnology company teamed up to develop alternatives models to study an inherited human heart disease

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,cure,enabling-technologies,life-science-and-biotechnologies,medical-technology,regenerative-medicine,

Advanced Delivery of RNA Lipid Nanoparticles (ADRNALIN)

2023

Biotech and universities jointly develop delivery vehicles for a better use of RNA as therapeutics

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,enabling-technologies,life-science-and-biotechnologies,pharmacotherapy,

DAta-driven Integrated Diagnostics And surveiLlance: eScaping the labyrinth of big data (DAIDALuS)

2023

Improving patient safety and preventing adverse events by leveraging data from diagnostic laboratories

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,cure,enabling-technologies,healthcare,pharmacotherapy,

A Novel Mobile Health Technology Ecosystem for the Treatment and Prevention of Cardiovascular Disease: The Connect@Heart Project

2021

Connect@Heart: A Novel Mobile Health Technology Ecosystem for the Treatment and Prevention of Cardiovascular Disease

Archief

,digital-and-information-technologies,healthcare,homecare,prevention,

Implant Support System for Cardiac Resynchronization Therapy

2020

Improving and validating new computerised heart modelling which improves the success of Cardiac Resynchronization Therapy

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,cure,digital-and-information-technologies,enabling-technologies,imaging,medical-technology,

Quantitative analysis of blood velocity in the retina.

Q-Flow: Quantitative Flow analyses in retinal vasculature.

2019

Blood flow velocity is an important indicator of retinal health

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,care,enabling-technologies,imaging,medical-technology,photonics-and-optical-technologies,

StressAutismMate (SAM), a digital health innovation

2018

The SAM-app gives adults with ASD insight in stress patterns and helps to reduce stress

Archief

,mission-ii-care-in-the-living-environment,

,care,digital-and-information-technologies,health-technology-assessment-and-quality-of-life,healthcare,homecare,

Oral health and mild intellectual disability.

Oral health in adolescents with mild intellectual disability.

2017

Worse than average oral health in adolescents with mild intellectual disability

Archief

,mission-i-lifestyle-and-living-environment,

,healthcare,life-science-and-biotechnologies,prevention,specialized-nutrition,

Technical support by exoskeletons for construction workers.

2018

Exoskeletons might Arm-support exoskeletons may lower the biomechanical load on low back and shoulders, but this is highly depending on the type of tasks and postures and movements involved

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,

,engineering-and-fabrication-technologies,health-technology-assessment-and-quality-of-life,healthcare,prevention,

Effect of exoskeletons in reducing the physical load in heavy work.

2017

Arm-support exoskeletons may lower the biomechanical load on low back and shoulders, but this is highly depending on the type of tasks and postures and movements involved

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,

,engineering-and-fabrication-technologies,health-technology-assessment-and-quality-of-life,healthcare,prevention,

Strengthen the sustainable employability of temporary agency workers.

Sustainable employability (SE) - the ability to participate healthily, vitally and productively in (paid) work until retirement age - in the long term strengthening of (low-skilled) temporary agency workers

2018

Strengthening the sustainable employability (SE) of temporary workers by developing an approach and an inventory of the preconditions for the temporary employment sector and bringing about behavioral change to invest in this

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,enabling-technologies,health-technology-assessment-and-quality-of-life,healthcare,prevention,

Women for women, share your health through your own vaginal bacteria

2022

In this project citizen scientists isolate own vaginal lactic acid bacteria to help other women improve vaginal health

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-ii-care-in-the-living-environment,

,healthcare,life-science-and-biotechnologies,one-health,prevention,

Healthier guts through prebiotics made by fungal enzymes.

Stimulating a healthy gut microbiome by using specific prebiotics generated by fungal enzymes

2022

Opening up a new approach to develop healthy foods using fungal enzymes

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-i-lifestyle-and-living-environment,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,health-technology-assessment-and-quality-of-life,life-science-and-biotechnologies,prevention,specialized-nutrition,

Ultrafast four-dimensions Electron Microscopy on Biological Samples.

2021

A 200ns Time Resolution Timepix4 Detector for Studying Biological Samples by Transmission Electron Microscopy

Archief

,mission-iii-participating-with-a-disease-or-disability,mission-iv-quality-of-life-for-people-with-dementia,

,enabling-technologies,imaging,life-science-and-biotechnologies,prevention,

SSc-ILD studie: De rol van ontsteking, fibrose en verkalkingen in de longen bij patiënten met Systemische Sclerose.

Assessing the role of interleukin-6 in local inflammatory and fibroproliferative changes in Systemic Sclerosis related Interstitial Lung Disease: a proof of concept study

2019

A pilot study to explore what is going on in the lungs of patients with scleroderma, to find potentially new disease targets.

Archief

,central-mission-5-30-doing-much-more-against-health-inequalities,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,life-science-and-biotechnologies,molecular-diagnostics,pharmacotherapy,prevention,

Pediatric cholestatic diseases studied and treated via genetic mouse models

Pediatric cholestatic diseases: Genetic models (PedChoGeM)

2022

The project aims to develop humanised mouse models for pediatric cholestatic diseases which will facilitate the development and testing of novel therapeutic strategies

Actief

,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,life-science-and-biotechnologies,pharmacotherapy,

Search for signal molecules that confirm antibiotic prescription necessity

Identification of biomarkers that differentiate between viral and bacterial respiratory infections.

2022

Discovery of biomarkers that guide antibiotic therapy is crucial for the future of antibiotics

Actief

,central-mission-5-30-doing-much-more-against-health-inequalities,

,medical-technology,molecular-diagnostics,one-health,prevention,

FLASH proton therapy to improve early-stage breast cancer treatment

Preclinical development and validation of ultra high dose rate FLASH proton therapy

2022

Delivering radiotherapy in a FLASH: enabling clinical translation by building advanced techniques and exploring effectiveness

Actief

,mission-iii-participating-with-a-disease-or-disability,

,cure,enabling-technologies,imaging,medical-technology,

Exploring the molecular landscape of COPD on single cell level

To identify the molecular and epigenetic changes underlying the disease pathology of COPD on a single cell level

2022

An integrated single nuclear RNA and ATAC sequencing approach to identify disease drivers of COPD

Actief

,mission-iii-participating-with-a-disease-or-disability,

,bio-pharma,cure,molecular-diagnostics,pharmacotherapy,

Smart Early Recognition of Sepsis SMARTER SEPSIS (Smart Early bed-side Recognition of Sepsis)

2022

Early sepsis recognition is lifesaving, but current diagnostic tools lack speed and accuracy

Actief

,mission-ii-care-in-the-living-environment,mission-iii-participating-with-a-disease-or-disability,

,care,healthcare,molecular-diagnostics,

Boosting resilience to age-related neurodegeneration

Finding interventions to boost resilience to age-related neurodegeneration

2022

This project explores how targeting tryptophan metabolism can boost resilience to neurodegeneration in a short-lived worm

Actief

,mission-iii-participating-with-a-disease-or-disability,mission-iv-quality-of-life-for-people-with-dementia,

,bio-pharma,enabling-technologies,pharmacotherapy,prevention,

Fibroblast growth factors to combat fatty liver disease

Targeting the fibroblast growth factor system in the treatment of non-alcoholic fatty liver disease (NAFLD)

2022

Metabolic fibroblast growth factors carry great potential as novel therapeutics in the treatment of non-alcoholic fatty liver disease

Actief

,mission-ii-care-in-the-living-environment,

,bio-pharma,cure,life-science-and-biotechnologies,pharmacotherapy,