PRIMO - Polymer resurfacing implant design translation and optimization using computational methods
The PRIMO project aids the development of joint resurfacing implants to decrease the burden of osteoarthritis
Avalanche Medical has developed a non-degradable polymer resurfacing implant intended for the treatment of knee focal cartilage defects. The implant is composed of a hard-grade polymer stem, for fixation in the underlying bone, and a soft-grade polymer articulating surface, mimicking the properties of cartilage. Theoretically, this implant concept can be translated to any human joint. The objective of the PRIMO project was to develop computational methods that enable translation of the implant design to other joints, accommodating the complex morphology of the articulating surface and the physiological loading conditions. Maastricht University Medical Center (MUMC+) has contributed by developing statistical shape models that will allow for generalization of the design for the broad patient population and for patient indication setting.
Ultimately, the newly developed implants will allow for the restoration of function and chronic pain relief in patients suffering from early stage joint disease. A joint resurfacing implant can postpone total joint arthroplasty, thereby leading to substantial cost-savings in the long-term. Direct costs related to complications associated with total joint replacement revision procedures and indirect costs related to loss of productivity can potentially be avoided, thereby contributing to the future management of osteoarthritis.
To successfully translate the implant concept to other joints, the two implant components (top- and bottom layer) require tailoring to the specific target location. Work package 1 has focused on developing computational methods that allow for matching the implant’s articulating surface to the morphology of the target joint surface. Work package 2 has developed methods to optimize the design of the implant’s stem, taking joint biomechanics and surgical considerations into account. Work package 3 has manufactured prototype implants.
Feasibility of this new workflow was demonstrated by conceptualizing one prototype implant design for the trochlea and by manufacturing prototypes of the trochlea implant design for evaluation in a laboratory environment.
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