Skin and Microbiome for Health
Arriving at a state-of-the-art translational integrated Human Microbiome - Human Skin Equivalent model systems suitable for Personal Care Product development and ingredient testing
In this project, we developed a new skin microbiome model for healthy skin, incorporating both the skin microbiome and cultured human skin. We demonstrated that a broad selection of skin microorganisms could grow on this model. Using a selection of microorganisms, we studied several aspects in more detail. Epidermal morphogenesis was affected by opportunistic microorganisms, whereas this remained well organized by co-culturing with commensal microorganisms.
We studied the reaction of skin tissue to the growth of skin microorganisms. We were able to show that there were species-specific reactions, with some species inducing a mild inflammatory response, while others did not.
Furthermore, we compared microbial growth on skin models of different complexities (only epidermis or both epidermis and dermis) and demonstrated that growth on the various models was comparable. Finally, we showed that we could influence the growth of skin microorganisms in the model.
In this project, we developed a model that allows for the investigation of the effects of substances on skin microorganisms and skin tissue without the need for animal testing. This model, which mimics healthy skin, can also be further developed to simulate specific skin diseases, enabling better study of these disease processes and screen for potential interventions.
Andere projecten
In elk PPS-project werken kennisinstellingen, bedrijven en zorgpartijen samen aan een concrete gezondheidsvraag. Bekijk het volledige projectoverzicht.
Bekijk de programma’s
Binnen onze programma’s werken bedrijven, kennisinstellingen en regionale partners samen aan innovaties die bijdragen aan betere gezondheid en zorg.
Bekijk de partnerschappen
Strategische publiek-private partnerschappen (PPP's) zijn meerjarige samenwerkingen tussen bedrijven, kennisinstellingen en andere partijen.
Hoe kunnen we je helpen?
Heb je een vraag of wil je meer weten over Health Holland? We brengen je graag in contact met de juiste mensen, kennis en mogelijkheden om gezondheidsinnovatie te versnellen.
We hebben uw bericht ontvangen
We nemen binnen 3 tot 4 werkdagen contact met je op. Is je vraag dringend? Neem dan gerust direct contact met ons op. Hieronder zie je de contactoptie die het beste past bij je onderwerp.
Opnieuw beginnen
Er ging iets mis bij het versturen van het formulier. Probeer het opnieuw.