Transcriptomic Overview of Target Antigens through Leukapheresis gathered Circulating Tumour Cells
Improving cancer care by minimally invasive measurement of protein expressions from circulating tumor cells
The University of Dusseldorf has shown that when extracting white blood cells from cancer patients through a procedure called leukapheresis, also cancer cells from the blood are collected. Ideally, this could be used to guide treatment. In this project, the Dutch start-up company FETCH will combine their magnetic separation technology for tumor cells with the expert knowledge of the University of Dusseldorf. Together, they will develop and test a method to determine the presence of treatment target proteins in metastatic cancer patients.
Selecting the right therapy for each patient has become of major importance. With the rise in targeted therapies, this requires information on the expression of treatment targets. By detecting these treatment targets on circulating tumor cells from the blood, their expression can monitored at several timepoints, allowing treatment adjustments when needed. In this project we will work on a test that can detect circulating tumor cells from the entire blood volume, resulting in a high sensitivity. As the number of treatment targets is still rapidly increasing, target independent analysis is preferred. For this, the consortium will use droplet based RNA-analysis, capable of determining the protein expression of thousands of cells from each patient. With this information, the oncologist can better determine which therapy should be used at this time, but also new treatment targets could be discovered.
By making it easier to determine the expression of treatment targets, we will be able to better guide therapy, resulting not only in a faster and better selection of the right treatment, but also in a reduction of in-effective treatments and unneeded side-effects.
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