Probiotic Regulation of Food Intake through Satiety Stimulation and Gut Microbiota Modulation
Effect of a newly formulated probiotic supplement on satiety and food intake
This unique research project will provide insight into the benefits of a newly formulated supplement for the regulation of food intake by combining expertise in food intake regulation and microbial composition from Maastricht University with expertise in the production of high-quality probiotics from Winclove, a company aiming to improve lives by making a sustainable impact worldwide.
According to the World Health Organization (WHO), obesity has reached epidemic proportions worldwide with more than 39% overweight (>1.9 billion) and 13% (>650 million) clinically obese adults. Societal costs of obesity with more than €79 billion per year for the Netherlands, affect the healthcare sector, but also include tremendous costs due to productivity losses. People living with obesity are sick more often and for longer periods of time, compared to people with a healthy weight. Therefore, there is a critical need for targeted nutritional strategies, which go beyond the selectively available pharmacological options, for the prevention of obesity. For this purpose, a new product has been developed with probiotic strains specifically selected based on their potential to influence hunger and satiety signaling. A total of 98 overweight/obese men and women will receive this probiotic supplement or a placebo for 16 weeks. Effects on food intake, satiety hormone release, and changes in the intestinal microbiota will be investigated.
A positive result will justify scaling up the development of this supplement and transforming it into a natural, cost-effective and sustainable product, available to a large part of the population, regardless of socio-economic status. This project has a) the unique and innovative opportunity to provide new hypotheses for the scientific community working to improve metabolic health in humans, b) delivers novel dietary strategies for consumers, and c) gives leads for product development for the treatment and prevention of metabolic disease.
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