Metastatic Melanoma-on-Chip
Metastatic Melanoma-on-Chip; in vitro miniature and parallelized industrial therapy-testing platform
In this project, Amsterdam UMC together with TissUse, a world-leading multi-organ-chip company, aim to develop a novel microfluidic metastatic melanoma-on-chip, with draining lymphatics and a reconstructed LN, to recapitulate early immune suppressive events upon melanoma development followed by testing of immune modulating drugs.
As the most aggressive form of skin cancer, melanoma is characterized by early immune suppression and metastasis. Treatment with systemic immune checkpoint blockade is effective for over half of the patients, but can cause at times substantial side effects. This emphasizes the need for specialized testing platforms to further develop and test novel therapeutics for melanoma treatment.
This platform will directly provide an animal alternative for academic researchers and industry. It is strongly expected that the in vitro miniature and industrial therapy-testing platform will reduce pharmaceutical R&D costs.
The project will start with the generation of a novel lymphatic vasculature-based microfluidics, connecting the melanoma and lymph node compartments, on the TissUse HUMIMIC-chip. Next, melanoma-skin model and lymph node models will be incorporated generating the metastatic melanoma-on-chip platform with relevant immune cells. Dynamic flow will enable tumor derived factors and metastasizing tumor cells to enter the lymph node via the lymphatics. Once established, immune modulating drugs will be applied to test immune activation against the tumor.
At the end of the project, a novel platform will have been generated that incorporates the complexity of melanoma-in-skin, its lymphatics, and tumor draining lymph nodes, including the relevant immune cells, into 1 single model system. This platform can be used to test novel therapeutics aimed at immune potentiation in early melanoma development.
For more information:
Amsterdam UMC, Locatie VUmc - Principal Investigators
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