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REPIC: RSV Entry Pathway in Human Ciliated Airway Cells
REPIC: RSV Entry Pathway in Human Ciliated Airway Cells

REPIC: RSV Entry Pathway in Human Ciliated Airway Cells

The search for roadblocks to viral infection of the human lung

Periode
-
Looptijd
24 months
Deel van call / Programma
/
Projectpartners
LUMC
Janssen

Leiden University Medical Center (LUMC) and Janssen Vaccines & Prevention B.V. have finished a research collaboration effort to improve the prevention of respiratory viral infections. During this research collaboration, novel host proteins involved in viral replication have been identified. More specifically, removing these proteins from the host cell (the cell being targeted by RSV) resulted in a complete blocking of the infection. These highly encouraging experimental outcomes have led to the design of a drug development program. The goal of this program is to develop small molecule drugs that inhibit the function of these proteins.

Furthermore, LUMC and Janssen Vaccines & Prevention B.V. have built an assay on genetically modified lung cells allowing to test new antiviral drugs in a highly sensitive manner. This assay will be taken along in the development of the drugs described in the previous paragraph.

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