Vectorized Antibody Treatment of Dementia in Synucleinopathies (VADemS) evaluated in Novel Parkinson model
Project aimed at assessing safety and efficacy of vectorized antibody treatment in Parkinson animal model
Research into a New Treatment for Parkinson’s Disease
In collaboration with the Netherlands Institute for Neuroscience and the Biomedical Primate Research Centre, Syngle is developing a new model to better study Parkinson’s disease. This model will be used to test Syngle’s new treatment involving special antibodies. The researchers hope to determine whether this treatment is safe and effective so that it can later be tested in humans.
Dementia is common among people with Parkinson’s disease. Approximately 24-50% of the 7 million patients worldwide experience it, and in later stages of the disease, this number rises to 80%. In addition to movement problems such as tremors and stiffness, memory loss is one of the most severe symptoms. Currently, there is no cure—only treatments that temporarily relieve symptoms.
Parkinson’s disease is caused by the accumulation of a protein called alpha-synuclein, which is toxic to brain cells. Syngle has developed a treatment designed to remove these harmful proteins. In earlier tests, this treatment was shown to protect brain cells and reduce movement problems. This new study aims to determine whether the treatment is also effective in a model that more closely resembles humans. If successful, the treatment can then be tested in people with Parkinson’s disease, with the goal of slowing or even stopping disease progression.
This project has two key objectives:
- Preparing Syngle’s new treatment for human trials.
- Developing a model that will allow scientists and drug developers to conduct further research on Parkinson’s and similar diseases in the future.
Both objectives contribute to finding better treatments for Parkinson’s disease.
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