Improving Device Localization in Ultrasound, CT, and MRI using a novel Multimodal Imaging coating for MEdical Devices (MIME)
Enabling safer, more accurate interventions with improved multimodal imaging of medical devices using one coating
The “Multimodal Imaging coating for MEdical devices” (MIME) project is aimed at improving medical device visibility in minimally-invasive procedures. The project develops a novel multimodal coating that enhances visibility across ultrasound, MRI, and CT imaging, an innovation currently unavailable on the market. The project is a public-private partnership between Sono-Coat BV, a SME offering ultrasound visible coatings tot the medical device industry, and the Radboud University Medical Center (RUMC), a leading Dutch university medical centre.
Minimally-invasive procedures are increasingly common due to their reduced recovery times and lower complication rates. However, they demand extremely high precision, especially in treatments involving vital organs or radioactive isotopes. Multimodal imaging—combining ultrasound, CT, and MRI—is often required to guide and confirm device placement. Yet, poor device visibility remains a challenge. For instance, in 21% of brachytherapy cases (a form of internal radiation therapy for cancer), clinicians report difficulties in locating the medical device. These visibility issues can lead to misdiagnosis, tissue damage, and repeated interventions, increasing patient risk and healthcare costs. Addressing this challenge is essential to improve treatment outcomes and patient comfort.
MIME addresses this unmet clinical need by developing a versatile coating that enables simultaneous visibility in ultrasound, MRI, and CT imaging. In collaboration with the RadboudUMC, Sono-Coat will adapt its echogenic technology for compatibility with additional imaging modalities. The enhanced visibility reduces the likelihood of misplacement, minimizes the need for repeated insertions, and supports more accurate and efficient procedures.
The MIME project will deliver a first-of-its-kind multimodal imaging coating for medical devices, validated through proof-of-concept testing. Key outcomes include:
• A modified coating formulation compatible with ultrasound, MRI, and CT.
• Preclinical validation data demonstrating improved device visibility.
• Application guidelines for integration into existing interventional workflows.
• A roadmap for clinical translation and commercialization.
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