The research and development and initial validation of a technique for accurate image guidance for biological therapies in the heart (A-BIOLOGIC-HEART)
Development of a new technology for accurate image guided delivery of cell and gene therapies in the heart
This international research project, supported by a newly established public-private partnership between the University Medical Centre Utrecht in the Netherlands and the Dutch MedTech company CART-Tech B.V., aims to develop an innovative image-guided platform, CARTBox IMD, for the safe and precise delivery of biological therapies—such as gene therapy and stem cell therapy—directly into the heart muscle. The collaboration unites scientific expertise, clinical insight, and technological innovation to accelerate the clinical translation of advanced cardiac treatments.
Cardiovascular diseases are the leading cause of death globally, responsible for nearly 18 million deaths per year according to the World Health Organization. While gene and stem cell therapies hold immense potential for regenerating damaged heart tissue, their clinical success is currently limited by poor delivery accuracy and procedural risks. Without precise targeting, these powerful treatments can miss their intended site, reduce effectiveness and increase the risk of side effects. Innovation in delivery technology is urgently needed to bridge the gap between promising therapies and patient benefit.
To address this challenge, the project introduces the CARTBox IMD platform—a cutting-edge image guidance system designed to support physicians during intramyocardial injections. The system combines 3D anatomical modelling, motion compensation, catheter tracking, and optimized real-time therapy guidance to ensure accurate and safe delivery of biological therapies. Experimental validation be done to test the system in clinically relevant scenarios.
Key deliverables include 3D heart models with integrated targeting features, real-time motion correction, precision tracking tools, and a comprehensive software platform. In parallel, a validated study report on safety and efficiency, and an investigational device dossier (IMDD), will pave the way toward regulatory approval. Ultimately, this project will enable safer, more effective regenerative heart therapies and enhance patient outcomes worldwide.
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