Statistical shape model development for polymer resurfacing implant design translation

Avalanche Medical has developed a non-degradable polymer resurfacing implant intended for the treatment of knee focal cartilage defects. The implant is composed of a hard-grade polymer stem, for fixation in the underlying bone, and a soft-grade polymer articulating surface, mimicking the properties of cartilage. Theoretically, this implant concept can be translated to any human joint. The objective of the current project is to develop computational methods that enable translation of the implant design to other joints, accommodating the complex morphology of the articulating surface and the physiological loading conditions. Maastricht University Medical Center (MUMC+) will contribute by developing statistical shape models that will allow for generalisation of the design for the broad patient population and for patient indication setting. 

Ultimately, the newly developed implants will allow for the restoration of function and chronic pain relief in patients suffering from early stage joint disease. A joint resurfacing implant can postpone total joint arthroplasty, thereby leading to substantial cost-savings in the long-term. Direct costs related to complications associated with total joint replacement revision procedures and indirect costs related to loss of productivity can potentially be avoided, thereby contributing to the future management of osteoarthritis. 

To successfully translate the implant concept to other joints, the two implant components (top- and bottom layer) require tailoring to the specific target location. Work package 1 will focus on developing computational methods that allow for matching the implant’s articulating surface to the morphology of the target joint surface.  Work package 2 will develop methods to optimize the design of the implant’s stem, taking joint biomechanics and surgical considerations into account. Work package 3 will manufacture prototype implants.

Feasibility of this new workflow will be demonstrated by conceptualising two prototype implant designs and by manufacturing prototypes of the implant designs for evaluation in a laboratory environment.