In muscle diseases, muscle fibers lose their capacity to contract, resulting in loss of mobility and respiration. In this project advanced 3D models of muscle diseases in vitro will be generated and the effects will be investigated on the smallest contractile unit present in muscle cells using highly sensitive force measurements.
The immune system has potent mechanisms with which it deals with intruding viruses, bacteria and tumors, protecting us from disease. However, tumors contain mutations leading to resistance to the immune system. The NextIO project aims to develop a medicine that restores the sensitivity of the cancer to the immune system.
The aim of this project was to develop methodologies for robust, and safe in vivo gene editing in skeletal muscle tissue. The project has provided a valuable tool set for researchers around the world to perform gene targeting in skeletal muscle, enabling the development of personalised gene therapies for genetic muscle disease and metabolic diseases.
Acute myeloid leukemia (AML) is a form of blood cancer that is still difficult to cure and better therapies against AML are clearly needed. As a continuation of a long-standing collaboration between the Schuringa lab at the UMCG and Janssen will exploit potential novel targets against leukemic stem cells.
Increasing evidence suggests that dynamic changes in the transcriptional state of specific cell-types plays a key role in determining disease outcomes. Here, cell-type specific changes will be detected in tuberous sclerosis complex cortical tubers and assessed if these cell-type changes are involved in the pathogenesis of epilepsy.
The aim is to improve vaccines by including viral innate immune antagonists that are co-expressed with the antigen to boost vaccine efficacy.
Current electronic pacemakers to treat patients whose native pacemaker dysfunctions due to ageing carry inherent limitations and risks of both medical complications and becoming ill-affordable due rising demands of the ageing population. LenitPace aims to solve these limitations and risks by developing virus-based methodologies to create a biological cardiac pacemaker.
Catecholaminergic Polymorphic Tachycardia is a genetic cardiovascular disease, often leading to sudden cardiac death, which is particularly difficult to study. The combination of human beating cardiac cells from patients and innovative screening assays can help identifying arrhythmia and drugs to prevent it using a personalized approach.
Addition of glycerol esters of short chain fatty acid (eSCFA) to pig feed has beneficial health effects and can thereby reduce the use of antibiotics in the farming industry. This project investigates which specific antimicrobial peptides are upregulated by eSCFA and determines how these peptides add to the health benefit.
In DiSSeMINATE, the aim is to increase the understanding of the spread of mobile genetic elements that carry antimicrobial resistance genes in and between humans, animals and the environment.