The project LIF2.0 aims to develop a short term response to COVID-19 needs in industry and public organisations by offering a real time COVID-19 driven data platform covering European wide aggregated content from a vast amount of sources. Users will have insights for developing new echo period strategies.
Increasing evidence suggests that dynamic changes in the transcriptional state of specific cell-types plays a key role in determining disease outcomes. Here, cell-type specific changes will be detected in tuberous sclerosis complex cortical tubers and assessed if these cell-type changes are involved in the pathogenesis of epilepsy.
This project was set up to understand why arthritis develops in some patients with psoriasis, by studying a broad array of clinical and immunological parameters in patients with psoriasis and psoriatic arthritis.
Pain reduction in the palliative phase is mostly achieved with opioids. However, these may not have adequate effects in some patients and cause severe side-effects that impair the ability to partake in social life. This project (re)introduces pituitary gland stimulation for pain relieve to achieve pain reduction without these side -effects.
This project aims to develop and produce a final finger blood collection system that meets all legal requirements for certification and is technically validated for best practices COVID-19 serology tests readily available on medical laboratories.
Angiotensin-II is a protein that plays a role in the development of acute lung injury in patients suffering from COVID-19 infection. Valsartan is a well-known, cheap drug in cardiovascular medicine with little side effects that blocks Angiotensin-II. This project investigates whether valsartan can prevent acute lung injury in COVID-19 infection.
A unique public-private consortium consisting of Leiden University Medical Center (LUMC), ISA Therapeutics, and Immunetune aims to develop advanced vaccines against SARS-CoV-2, causing the pandemic COVID-19, and against other human coronaviruses. The vaccine is built on the combination of two strong synthetic vaccine platforms and the inclusion of conserved T and B cell epitopes to provide both humoral and cellular defenses against coronaviruses.
It is proposed to develop a technology for real time guidance during cancer surgery. A probe will be developed that informs the surgeon realtime on the tissue type underneath the instrument. This will be achieved by strategically combining ultrasound imaging with the accurate tissue sensing capabilities of optical spectroscopy within one handheld device.
The project will explore strategies to cure HIV via eliminating the HIV reservoir through induced cell death or through induced cell killing.
Hospitalisation is often linked with loss of functional independence due to sarcopenia. Geriatric rehabilitation following acute disease, offers the opportunity to combat sarcopenia. The public-private consortium EMPOWER-GR aims to understand barriers/enablers diagnosing in treating sarcopenia. It also aims to intervene and evaluate a combined nutritional and exercise intervention. And finally its aim is to share knowledge about sarcopenia.