This multidisciplinary PPP focuses on the reduction of the SARS-CoV-2 transmission risk for athletes and spectators in semi-indoor and indoor sports venues, with emphasis on football stadiums, indoor halls and fitness centers. Crowd control, air cleaning and face masks are considered, either separately or combined, in five practical case studies.
Atherosclerosis is the main underlying cause of cardiovascular disease (CVD) and due to its multifactorial natural is often studied in animal models. Here the aim is to develop an innovative ex vivo system to study the atherosclerotic disease process based on the actual human atherosclerotic plaque. In line with the Transition to Animal-free Innovation (TPI), the aim is to develop a model that generates data on the effect of novel drugs that is highly translatable to the effect of the novel drug in the cardiovascular patient, while at the same time minimising the number of laboratory animals used. Moreover, the aim is to utilise this model to discover new biomarkers of successful treatment, which could expedite the transition of CVD therapeutic into clinical trial.
The IMAGEN consortium aims to improve diagnostics of patients with ciliopathies and tubulopathies, enhance quality of care, and translate genetic findings to personalised care by testing pharmacological treatment approaches based on patient-derived disease models.
Worldwide, venomous snakebites claim about 125.000 deaths and maim 450.000 people yearly, mostly in poor rural areas, for which there is no safe and adequate treatment. This situation will be alleviated by developing human antibodies which will be safe and much better than the current treatments.
The Follow The Dot project evaluates the use of Virtual Reality in EMDR (VR-based EMDR) in children with post-traumatic stress symptoms in a multicenter Randomized Controlled Trial (RCT). VR-based EMDR stimulates self-care in the family setting and is expected to reduce symptom recurrence, enhance patient satisfaction and improve quality of life.
The knowledge is missing that is essential for cost-effective roll-out of personalised treatment of insomnia. This project solves the bottleneck by creating a research platform for combined online behavioural change intervention and long-term monitoring of sleep, traits and health. A growing database will allow for optimised sleep interventions tailor to personalised needs, capacities, limitations and estimated benefits.
In muscle diseases, muscle fibers lose their capacity to contract, resulting in loss of mobility and respiration. In this project advanced 3D models of muscle diseases in vitro will be generated and the effects will be investigated on the smallest contractile unit present in muscle cells using highly sensitive force measurements.
The immune system has potent mechanisms with which it deals with intruding viruses, bacteria and tumors, protecting us from disease. However, tumors contain mutations leading to resistance to the immune system. The NextIO project aims to develop a medicine that restores the sensitivity of the cancer to the immune system.
The aim of this project was to develop methodologies for robust, and safe in vivo gene editing in skeletal muscle tissue. The project has provided a valuable tool set for researchers around the world to perform gene targeting in skeletal muscle, enabling the development of personalised gene therapies for genetic muscle disease and metabolic diseases.
This project aims to unravel mechanisms underlying beneficial effects of a novel food supplement on cognitive performance. This may contribute to the prevention of cognitive impairment and ultimately dementia. Focus will be on adults with an emerging pre-mild cognitive impairment condition who will benefit most from evidence-based intervention and prevention strategies.