The Follow The Dot project evaluates the use of Virtual Reality in EMDR (VR-based EMDR) in children with post-traumatic stress symptoms in a multicenter Randomized Controlled Trial (RCT). VR-based EMDR stimulates self-care in the family setting and is expected to reduce symptom recurrence, enhance patient satisfaction and improve quality of life.
The knowledge is missing that is essential for cost-effective roll-out of personalised treatment of insomnia. This project solves the bottleneck by creating a research platform for combined online behavioural change intervention and long-term monitoring of sleep, traits and health. A growing database will allow for optimised sleep interventions tailor to personalised needs, capacities, limitations and estimated benefits.
In muscle diseases, muscle fibers lose their capacity to contract, resulting in loss of mobility and respiration. In this project advanced 3D models of muscle diseases in vitro will be generated and the effects will be investigated on the smallest contractile unit present in muscle cells using highly sensitive force measurements.
The immune system has potent mechanisms with which it deals with intruding viruses, bacteria and tumors, protecting us from disease. However, tumors contain mutations leading to resistance to the immune system. The NextIO project aims to develop a medicine that restores the sensitivity of the cancer to the immune system.
The aim of this project was to develop methodologies for robust, and safe in vivo gene editing in skeletal muscle tissue. The project has provided a valuable tool set for researchers around the world to perform gene targeting in skeletal muscle, enabling the development of personalised gene therapies for genetic muscle disease and metabolic diseases.
This project aims to unravel mechanisms underlying beneficial effects of a novel food supplement on cognitive performance. This may contribute to the prevention of cognitive impairment and ultimately dementia. Focus will be on adults with an emerging pre-mild cognitive impairment condition who will benefit most from evidence-based intervention and prevention strategies.
Replacing current invasive testing by a simple blood test to enable prenatal diagnosis for pregnant couples carrying severe monogenic diseases, is much desired. In this project the aim is to develop an efficient NIPD method for monogenic diseases, for implementation in the clinic.
Acute myeloid leukemia (AML) is a form of blood cancer that is still difficult to cure and better therapies against AML are clearly needed. As a continuation of a long-standing collaboration between the Schuringa lab at the UMCG and Janssen will exploit potential novel targets against leukemic stem cells.
The aim is to improve vaccines by including viral innate immune antagonists that are co-expressed with the antigen to boost vaccine efficacy.
A fully automated microscopy and image analyses pipeline was developed for cultured human neurons. The findings show that human neurons with a molecular alteration that is specific for frontotemporal dementia show changes in connectivity that may be an important early causal factor in the disease.