The cancer grade, provided by pathologists, is the most important predictor of patient outcome, but suffers from inter- and intra-pathologist variability, reducing its usefulness for individual patients. An expert-level AI system will be provided to support pathologist and help reduce this variability and make their diagnostic practice more accurate and efficient.
The knowledge is missing that is essential for cost-effective roll-out of personalised treatment of insomnia. This project solves the bottleneck by creating a research platform for combined online behavioural change intervention and long-term monitoring of sleep, traits and health. A growing database will allow for optimised sleep interventions tailor to personalised needs, capacities, limitations and estimated benefits.
The immune system has potent mechanisms with which it deals with intruding viruses, bacteria and tumors, protecting us from disease. However, tumors contain mutations leading to resistance to the immune system. The NextIO project aims to develop a medicine that restores the sensitivity of the cancer to the immune system.
This project aims to unravel mechanisms underlying beneficial effects of a novel food supplement on cognitive performance. This may contribute to the prevention of cognitive impairment and ultimately dementia. Focus will be on adults with an emerging pre-mild cognitive impairment condition who will benefit most from evidence-based intervention and prevention strategies.
Replacing current invasive testing by a simple blood test to enable prenatal diagnosis for pregnant couples carrying severe monogenic diseases, is much desired. In this project the aim is to develop an efficient NIPD method for monogenic diseases, for implementation in the clinic.
Acute myeloid leukemia (AML) is a form of blood cancer that is still difficult to cure and better therapies against AML are clearly needed. As a continuation of a long-standing collaboration between the Schuringa lab at the UMCG and Janssen will exploit potential novel targets against leukemic stem cells.
Increasing evidence suggests that dynamic changes in the transcriptional state of specific cell-types plays a key role in determining disease outcomes. Here, cell-type specific changes will be detected in tuberous sclerosis complex cortical tubers and assessed if these cell-type changes are involved in the pathogenesis of epilepsy.
Ex-COVID-19 patients will undergo medical tests and biological samples will be analysed to increase the understanding of who is at risk for chronic disease. The influence of environmental factors and of a lifestyle intervention will be analysed, and lab research will contribute to better mechanistic insights providing leads for interventions.
Orthotics, like orthopaedic shoes or orthoses, are commonly prescribed to further improve balance and gait in these patients. To optimise the process of prescription and evaluation of orthotics, it is important to analyse the functional disorders objectively. Therefore, the purpose of this project is to optimise the orthotic design process by developing a decision tool for orthotics, which is called the GaReC.
This project was set up to understand why arthritis develops in some patients with psoriasis, by studying a broad array of clinical and immunological parameters in patients with psoriasis and psoriatic arthritis.