Unsuccessful clearance of hepatitis B virus in chronic patients leads to serious liver problems including liver cancer. Boosting and/or inducing T cell responses against multiple conserved viral antigens with Synthetic Long Peptide immunotherapy may offer a cure. Together Erasmus MC and ISA pharmaceuticals designed and validated the active ingredients.
MRI of the prostate is one of the best available methods to detect significant prostate cancer and its use will substantially increase for the next coming years. This project investigates new AI techniques for faster and more accurate MRI of the prostate for diagnostic and interventional purposes.
The mission of ABOARD is to jumpstart Personalised Medicine for Alzheimer’s disease by preparing for and investing in effective, efficient and patient-orchestrated diagnosis, prediction and prevention.
The consortium developed an easy and quickly applicable webbased tool for medical care professionals to screen their patients for periodontitis (www.parodontitisscreening.nl). Initial validation showed reasonable specificity and sensitivity, further studies in a new hospital will validate the algorithm behind the tool.
Human induced pluripotent stem cells hold promise for personalised medicine but differentiation efficiency towards specific cell types varies significantly between patients. Here, image based approaches were developed to monitor and determine cues for efficient differentiation towards heart and blood vessel cell types.
Hereditary diseases in dogs and humans are very similar. Genetic studies in dogs are a powerful tool to identify new mutations for complex hereditary diseases. Comparing results from canine and human genetic studies will lead to an acceleration in identification of disease-causing mutations and subsequently improve diagnostics in both species.
IDCY contributed to the creation of an electronic database, www.theyeasts.org, containing information on yeast biodiversity that is freely available. These data include phenotypic data, pictures, molecular barcodes, MALDI-TOF MS spectra, MIC values for antifungals, and nucleotide sequences of resistance-related genes. Theyeasts.org will contribute users to identify unknown yeasts correctly.
This project aims to develop an approach to cancer therapy which is not based on combinations of drugs, but rather on the sequential treatment with drugs, thereby avoiding drug combination toxicity. A first drug will induce senescence in the cancer cells, the second drug will kill the senescent cancer cells.
Electronic data exchange is important to provide good healthcare. This project investigated the client’s needs in giving consent for data exchange. User studies were conducted and a privacy dashboard has been designed and evaluated. The clients experienced more control over the data exchange process by using the dashboard.
In this project inhalation medicines for patients with confirmed SARS-CoV-2 infection will be build that will aggregate SARS-2 virus particles, preventing their spread via aerosols. The nanomedicine system COVABELP will develop can be easily adapted to fight other pulmonary viruses and will also be used for diagnostic testing.