The aim is to improve vaccines by including viral innate immune antagonists that are co-expressed with the antigen to boost vaccine efficacy.
Ex-COVID-19 patients will undergo medical tests and biological samples will be analysed to increase the understanding of who is at risk for chronic disease. The influence of environmental factors and of a lifestyle intervention will be analysed, and lab research will contribute to better mechanistic insights providing leads for interventions.
The goal of this trusted guide to the world of COVID-19 is to help clinicians, the scientific community, policy makers and politicians and the public at large to get near real time accurate, expert-annotated and specific information in a modern, user friendly and easily accessible format. The benefits will include better use of treatments, faster development of vaccines and a clearer view on factors that may negatively affect the outcomes of a COVID-19 infection and other future virus outbreaks.
The human pluripotent stem cell derived heart models will be used for a rapid evaluation of important COVID-19 therapies and develop SARS-COV-2 disease models to investigate how infection affects the heart. Impact beyond conventional approaches will be accelerated by providing data immediately relevant to clinicians, within months of the project start.
There is a high demand for SARS-CoV-2 antiviral therapies that may limit COVID-19 severity in susceptible individuals. In this project, epithelial models from nasal brushing obtained from SARS-CoV-2 infected individuals will be developed. These models may allow simulation of viral infections in a dish and selection of candidate antiviral drugs.
This proposal aims at developing a simple and fast diagnostic method for SARS-CoV-2, aiming at efficient and large-scale testing in society. Cellulose-based virus capturing is combined with two methods for detection: isothermal amplification (RT-LAMP), and ultrafast PCR and used for Point-of-Care testing.
COVID-19 is taking a huge toll among healthcare workers worldwide: researchers are warning that the coronavirus pandemic could inflict posttraumatic stress disorder on an unprecedented global scale. Here, the aim is to implement a novel treatment strategy – that yields long-term cure within a single treatment-session – for traumatised healthcare workers during COVID-19.
Viral pneumonias (eg. COVID-19) have unpredictable disease courses and can be extremely severe because of tissue damage induced by the virus or hyperactivation of the host immune system. The point-of-care (SEH) 24/7 fully automated flow analysis allows fast immune profiling to monitor deterioration of disease on the ward and ICU.
This project aims to develop and produce a final finger blood collection system that meets all legal requirements for certification and is technically validated for best practices COVID-19 serology tests readily available on medical laboratories.
Addition of glycerol esters of short chain fatty acid (eSCFA) to pig feed has beneficial health effects and can thereby reduce the use of antibiotics in the farming industry. This project investigates which specific antimicrobial peptides are upregulated by eSCFA and determines how these peptides add to the health benefit.