To help in the battle against COVID-19, a novel compact CT scanner will be developed to rapidly screen for disease patterns and monitor disease progression. This is done by developing a new type of compact mobile CT scanner, equipped with artificial intelligence software to detect disease patterns accurately.
In muscle diseases, muscle fibers lose their capacity to contract, resulting in loss of mobility and respiration. In this project advanced 3D models of muscle diseases in vitro will be generated and the effects will be investigated on the smallest contractile unit present in muscle cells using highly sensitive force measurements.
The immune system has potent mechanisms with which it deals with intruding viruses, bacteria and tumors, protecting us from disease. However, tumors contain mutations leading to resistance to the immune system. The NextIO project aims to develop a medicine that restores the sensitivity of the cancer to the immune system.
Replacing current invasive testing by a simple blood test to enable prenatal diagnosis for pregnant couples carrying severe monogenic diseases, is much desired. In this project the aim is to develop an efficient NIPD method for monogenic diseases, for implementation in the clinic.
Acute myeloid leukemia (AML) is a form of blood cancer that is still difficult to cure and better therapies against AML are clearly needed. As a continuation of a long-standing collaboration between the Schuringa lab at the UMCG and Janssen will exploit potential novel targets against leukemic stem cells.
Increasing evidence suggests that dynamic changes in the transcriptional state of specific cell-types plays a key role in determining disease outcomes. Here, cell-type specific changes will be detected in tuberous sclerosis complex cortical tubers and assessed if these cell-type changes are involved in the pathogenesis of epilepsy.
The aim is to improve vaccines by including viral innate immune antagonists that are co-expressed with the antigen to boost vaccine efficacy.
Ex-COVID-19 patients will undergo medical tests and biological samples will be analysed to increase the understanding of who is at risk for chronic disease. The influence of environmental factors and of a lifestyle intervention will be analysed, and lab research will contribute to better mechanistic insights providing leads for interventions.
The goal of this trusted guide to the world of COVID-19 is to help clinicians, the scientific community, policy makers and politicians and the public at large to get near real time accurate, expert-annotated and specific information in a modern, user friendly and easily accessible format. The benefits will include better use of treatments, faster development of vaccines and a clearer view on factors that may negatively affect the outcomes of a COVID-19 infection and other future virus outbreaks.
The human pluripotent stem cell derived heart models will be used for a rapid evaluation of important COVID-19 therapies and develop SARS-COV-2 disease models to investigate how infection affects the heart. Impact beyond conventional approaches will be accelerated by providing data immediately relevant to clinicians, within months of the project start.