This project is aimed at designing bioelectronic medicines to control inflammatory biological processes and treat Inflammatory bowel disease (IBD) by applying electrical impulses.
Cognitive impairment is a major problem for psychiatric patients, affecting their daily lives. The current study investigates a possible solution in the form of a newly developed online cognitive training game and assessment tool that can be easily completed from home.
The presence of potentially pathogenic bacteria and an indwelling catheter predisposes to the development of a nosocomial UTI. This project aims for the development of an antimicrobial coating which can be applied to the surface of catheters in order to reduce the risk of urinary tract infections.
Robot-assisted surgery is becoming an accepted treatment modality in prostate cancer and its accuracy can be refined using fluorescence guidance. In this project we translated a robot-compatible hybrid surgical guidance technology that can be used to guide the urologist to the lymph nodes that are most likely to contain tumor metastases.
The aim of this project was to assess the clinical potential of therapeutic approaches for which we had confirmation of therapeutic effect potential in cell models. The focus was on genetic neuromuscular diseases, Huntington disease and CADASIL, a form of early onset stroke and dementia
HIV-infected pregnant women need to take medicines to prevent transmission of the virus to the child. However, standard therapy may not be adequate, and drugs could harm the fetus. Because experimental research in pregnancy is unethical, we aim to use alternative methods to develop optimal treatment of HIV-infected pregnant women.
Gelatin nanospheres have recently emerged as promising carriers for (targeted) local delivery of therapeutic biomolecules. The project has confirmed that gelatin nanospheres can be produced at industrial scale.
The prediction of substantial communication benefits after cochlear implantation in the deaf is still a clinical dilemma. By applying the only neuroimaging method that is insensitive to electromagnetic artefacts caused by the implant (near-infrared spectroscopy), the activity of the deaf brain can be viewed during listening after cochlear implantation.
A cochlear implant (CI) converts sound into an electrical signal which travels via the auditory nerve towards the brain. For this reason it is essential that a minimal amount of healthy auditory neurons is present in the cochlea, which is often not the case in hearing-impaired patients. We hypothesize that CI patients can benefit from stem-cell-based therapy to repair the auditory nerve.
A TB clinical decision system (CAD4TB+) has been developed for rapid screening of TB suspects. The system automatically analyses a chest radiography and by combining the result with other TB indicators - like HIV status and age - gives a nominal score between 0-100, the higher the score the more likely it is a TB suspect actually has the disease.