A new animal free alternative to study atherosclerosis

Atherosclerosis is the main underlying cause of cardiovascular disease (CVD) and due to its multifactorial natural is often studied in animal models. Here the aim is to develop an innovative ex vivo system to study the atherosclerotic disease process based on the actual human atherosclerotic plaque. In line with the Transition to Animal-free Innovation (TPI), the aim is to develop a model that generates data on the effect of novel drugs that is highly translatable to the effect of the novel drug in the cardiovascular patient, while at the same time minimising the number of laboratory animals used. Moreover, the aim is to utilise this model to discover new biomarkers of successful treatment, which could expedite the transition of CVD therapeutic into clinical trial.

Stimulation of the pituitary gland for pain reduction in the last phase of life

Pain reduction in the palliative phase is mostly achieved with opioids. However, these may not have adequate effects in some patients and cause severe side-effects that impair the ability to partake in social life. This project (re)introduces pituitary gland stimulation for pain relieve to achieve pain reduction without these side -effects.

Trusted World of Corona

The goal of this trusted guide to the world of COVID-19 is to help clinicians, the scientific community, policy makers and politicians and the public at large to get near real time accurate, expert-annotated and specific information in a modern, user friendly and easily accessible format. The benefits will include better use of treatments, faster development of vaccines and a clearer view on factors that may negatively affect the outcomes of a COVID-19 infection and other future virus outbreaks.

CLEAR COVID-19

There is a high demand for SARS-CoV-2 antiviral therapies that may limit COVID-19 severity in susceptible individuals. In this project, epithelial models from nasal brushing obtained from SARS-CoV-2 infected individuals will be developed. These models may allow simulation of viral infections in a dish and selection of candidate antiviral drugs.