In muscle diseases, muscle fibers lose their capacity to contract, resulting in loss of mobility and respiration. In this project advanced 3D models of muscle diseases in vitro will be generated and the effects will be investigated on the smallest contractile unit present in muscle cells using highly sensitive force measurements.
The aim of this project was to develop methodologies for robust, and safe in vivo gene editing in skeletal muscle tissue. The project has provided a valuable tool set for researchers around the world to perform gene targeting in skeletal muscle, enabling the development of personalised gene therapies for genetic muscle disease and metabolic diseases.
Current electronic pacemakers to treat patients whose native pacemaker dysfunctions due to ageing carry inherent limitations and risks of both medical complications and becoming ill-affordable due rising demands of the ageing population. LenitPace aims to solve these limitations and risks by developing virus-based methodologies to create a biological cardiac pacemaker.
To assess the efficacy of combined ingestion of whey plus collagen protein increase both myofibrillar and collagen protein synthesis rates in skeletal muscle tissue
Wound deepening through a lack of blood circulation in the affected skin, frequently occurs after burn injury and is associated with an adverse outcome. In this project it will be unveiled how certain white blood cells cause wound deepening and will test therapies that inhibit this process to improve the outcome.
Minimal fetal surgery is a promising medical technology to treat children before birth. Puncture of fetal membranes, however, introduces a risk of membrane rupture that may trigger premature birth (the achilles heel of fetoscopic surgery). A plug will be developed and clinically evaluated that closes the membranes after fetoscopic surgery.
A library of peptides will be screened to identify suitable candidates that could efficiently exert the delivery of mRNA to Natural killer cells. This approach will then be used to generate engineered natural killer cells that could be used for cancer immune-therapy by using overexpression or gene editing strategies.
The aim of this project is to develop methodologies for robust, and safe gene editing in human immune cells, particularly T‐cells. The results of the project provide a valuable toolset for researchers around the world to perform gene targeting in a wide variety of cells, enabling the development of personalised gene therapies and specific anti‐tumor immune therapies.
Liver transplantation is the only effective treatment for end-stage liver conditions, but donor organs are desperately lacking. An innovative solution is urgently needed. The aim is to bioengineering functional liver tissue in a closed loop perfusion system, using biological liver scaffolds and a patient’s own stem cells.
The complementary consortium of scientists, engineers and business people aim to accelerate the introduction of regenerative medicine into the clinic by automated cell culture upscaling. This project develops such an enabling technology with a unique combination of features: affordable, modular, compact and combined fluid management with excellent microscopy.