A technology preventing rupture of fetal membranes in fetoscopic surgery

Minimal fetal surgery is a promising medical technology to treat children before birth. Puncture of fetal membranes, however, introduces a risk of membrane rupture that may trigger premature birth (the achilles heel of fetoscopic surgery). A plug will be developed and clinically evaluated that closes the membranes after fetoscopic surgery.

A synthetic RNA delivery platform for universal ex vivo modification of natural killer cells

A library of peptides will be screened to identify suitable candidates that could efficiently exert the delivery of mRNA to Natural killer cells. This approach will then be used to generate engineered natural killer cells that could be used for cancer immune-therapy by using overexpression or gene editing strategies.