Hubrecht Organoid Technology and GlaxoSmithKline will together develop a human relevant Lung and Colon Immuno-Oncology model using Tumor Organoids, to better predict drug effectiveness for small molecule therapies.
The IMAGEN consortium aims to improve diagnostics of patients with ciliopathies and tubulopathies, enhance quality of care, and translate genetic findings to personalised care by testing pharmacological treatment approaches based on patient-derived disease models.
Hepatocellular carcinoma is the most frequent liver malignancy and the fourth most common cause of cancer-related death worldwide. There is a clear clinical need for accessible and reliable parameters to identify high-risk populations in order to decrease the high mortality rates of hepatocellular carcinoma.
The immune system has potent mechanisms with which it deals with intruding viruses, bacteria and tumors, protecting us from disease. However, tumors contain mutations leading to resistance to the immune system. The NextIO project aims to develop a medicine that restores the sensitivity of the cancer to the immune system.
Replacing current invasive testing by a simple blood test to enable prenatal diagnosis for pregnant couples carrying severe monogenic diseases, is much desired. In this project the aim is to develop an efficient NIPD method for monogenic diseases, for implementation in the clinic.
A fully automated microscopy and image analyses pipeline was developed for cultured human neurons. The findings show that human neurons with a molecular alteration that is specific for frontotemporal dementia show changes in connectivity that may be an important early causal factor in the disease.
Ex-COVID-19 patients will undergo medical tests and biological samples will be analysed to increase the understanding of who is at risk for chronic disease. The influence of environmental factors and of a lifestyle intervention will be analysed, and lab research will contribute to better mechanistic insights providing leads for interventions.
This project was set up to understand why arthritis develops in some patients with psoriasis, by studying a broad array of clinical and immunological parameters in patients with psoriasis and psoriatic arthritis.
Catecholaminergic Polymorphic Tachycardia is a genetic cardiovascular disease, often leading to sudden cardiac death, which is particularly difficult to study. The combination of human beating cardiac cells from patients and innovative screening assays can help identifying arrhythmia and drugs to prevent it using a personalized approach.
This proposal aims at developing a simple and fast diagnostic method for SARS-CoV-2, aiming at efficient and large-scale testing in society. Cellulose-based virus capturing is combined with two methods for detection: isothermal amplification (RT-LAMP), and ultrafast PCR and used for Point-of-Care testing.