Hubrecht Organoid Technology and GlaxoSmithKline will together develop a human relevant Lung and Colon Immuno-Oncology model using Tumor Organoids, to better predict drug effectiveness for small molecule therapies.
To help in the battle against COVID-19, a novel compact CT scanner will be developed to rapidly screen for disease patterns and monitor disease progression. This is done by developing a new type of compact mobile CT scanner, equipped with artificial intelligence software to detect disease patterns accurately.
The cancer grade, provided by pathologists, is the most important predictor of patient outcome, but suffers from inter- and intra-pathologist variability, reducing its usefulness for individual patients. An expert-level AI system will be provided to support pathologist and help reduce this variability and make their diagnostic practice more accurate and efficient.
A fully automated microscopy and image analyses pipeline was developed for cultured human neurons. The findings show that human neurons with a molecular alteration that is specific for frontotemporal dementia show changes in connectivity that may be an important early causal factor in the disease.
Image-guided external beam radiotherapy has the potential to considerably improve therapy delivery. This project is focused on dedicated image processing and dose accumulation algorithms that allow to exploit these possibilities in difficult anatomical areas.
The human pluripotent stem cell derived heart models will be used for a rapid evaluation of important COVID-19 therapies and develop SARS-COV-2 disease models to investigate how infection affects the heart. Impact beyond conventional approaches will be accelerated by providing data immediately relevant to clinicians, within months of the project start.
This proposal aims at developing a simple and fast diagnostic method for SARS-CoV-2, aiming at efficient and large-scale testing in society. Cellulose-based virus capturing is combined with two methods for detection: isothermal amplification (RT-LAMP), and ultrafast PCR and used for Point-of-Care testing.
Viral pneumonias (eg. COVID-19) have unpredictable disease courses and can be extremely severe because of tissue damage induced by the virus or hyperactivation of the host immune system. The point-of-care (SEH) 24/7 fully automated flow analysis allows fast immune profiling to monitor deterioration of disease on the ward and ICU.
A successful societal uptake of digital eye health requires a robust and safe telemonitoring platform that addresses the needs of its users. Patients request a simple tool that works intuitively with little external instructions. Doctors need a dataflow fully integrated in the electronic health record, and both need to develop trust in the validity and safety of remote monitoring. These requirements are addressed in this project.
Upon the development of a fatty liver, insulin does not suppress hepatic glucose production as efficient as it did before. However, it is yet unclear how glucose uptake is affected, which can be visualized by PET-CT measurements.