LSH Projects | Health~Holland

Optical biopsy using very short laser pulses

Central Mission: +5, -30 Doing much more against health inequalities
Mission I: Lifestyle and living environment
Mission II: Care in the living environment
Fundamental

We investigate the potential of ultrafast-spectroscopy for improved medical diagnostics using the fastest available light detector

Breathalyser-based Digital Biomarker for Alcohol Treatment

Central Mission: +5, -30 Doing much more against health inequalities
Mission I: Lifestyle and living environment
Mission II: Care in the living environment
Mission III: Participating with a disease or disability

A digital tool predicting alcohol relapse using clinical background, daily breathalyser samples and machine learning

AI-DBS: Applying Personalised Deep Brain Stimulation using ‘Neuronal Fingerprints’

Central Mission: +5, -30 Doing much more against health inequalities
Mission II: Care in the living environment
Mission III: Participating with a disease or disability
Fundamental

In this project we make deep brain stimulation intelligent by only stimulating when necessary

A new patient-friendly test for anal cancer screening

Mission III: Participating with a disease or disability
Experimental
Healthcare
Prevention

Developing a patient-friendly DNA methylation test to detect anal (pre)cancer in high-risk patients

KINDA (KINematic DBS Algorithm)

Central Mission: +5, -30 Doing much more against health inequalities
Mission II: Care in the living environment
Mission III: Participating with a disease or disability
Fundamental

AI-driven DBS for Parkinson’s: personalized, automated treatment using brain signals and video-based symptom tracking

Tumor microenvironment profiling for improved treatment selection in cervical cancer

Central Mission: +5, -30 Doing much more against health inequalities
Fundamental
Healthcare
Care

Affordable RNA profiling enables precise tumor microenvironment characterization for cervical cancer treatment optimization

Improving Alzheimer’s blood tests by accounting for personal differences

Central Mission: +5, -30 Doing much more against health inequalities
Mission IV: Quality of life for people with dementia
Experimental
Healthcare

Can personal protein markers improve Alzheimer’s blood test reliability?

Safe and effective immunotherapy for glioblastoma

Central Mission: +5, -30 Doing much more against health inequalities
Fundamental
Industrial
Healthcare

A novel, spatially-restricted, effective combinatorial CAR-T strategy to target GBM heterogeneity via nanobodies

A simple urine test to detect endometrial cancer

Central Mission: +5, -30 Doing much more against health inequalities
Mission II: Care in the living environment
Experimental
Healthcare

This project aims to identify novel DNA methylation markers in urine that distinguish women with endometrial cancer from those without. Using advanced technologies, we will develop a non-invasive, PCR-based urine test to improve early detection and reduce unnecessary diagnostic procedures in women with postmenopausal bleeding.

Pathological sensitivity of MRI biomarkers in Alzheimer’s disease

Central Mission: +5, -30 Doing much more against health inequalities
Mission II: Care in the living environment
Mission III: Participating with a disease or disability
Mission IV: Quality of life for people with dementia

How sensitive is MRI for underlying pathological mechanisms in Alzheimer’s disease?