Regenerative Extraluminal Connection for Endovascular CTO Treatment

The RECONNECT project brings together academic and industry partners, namely, Eindhoven University of Technology and STENTiT, to develop an innovative minimally invasive treatment for patients with severe Peripheral Artery Disease (PAD) in the lower legs. By combining computational modelling with pre-clinical testing, this public-private partnership aims to create a regenerative bypass that restores blood flow and prevents limb amputations.

Chronic Limb-Threatening Ischemia (CLTI) is the most advanced stage of PAD, a condition that restricts blood flow to the lower limbs. Every year, this leads to more than 250.000 amputations in the EU and US. Many of these amputations occur in vulnerable groups such as people with diabetes or kidney problems, who face a much higher risk. Current treatments often fail to restore circulation in complex blocked arteries, leading to pain, wounds, and loss of mobility. Aside from its heavy impact on quality of life, these amputations place a huge financial burden on society.

RECONNECT introduces a new solution: a regenerative bypass that transforms one of the patient’s own veins into a living artery. This minimally invasive approach could succeed where current methods fail, particularly in patients with long and complex blockages. By restoring blood flow, it aims to prevent amputations, reduce pain, improve mobility, and offer patients a healthier and more independent future.

The project will deliver a tested regenerative implant, supported by preclinical studies and computational models. Alongside these scientific results, RECONNECT will generate valuable insights into vascular regeneration, strengthen the Dutch Life Sciences & Health sector, and open new opportunities for future medical technologies.

Ultimately, the project aims to change the standard of care, improve patient lives, and reduce healthcare costs worldwide.

For more information: https://www.stentit.com/