AI tools for better, more accurate gene editing

PRIME-AI: Optimizing guideRNA design with AI to enhance gene editing

PRIME-AI is an exciting new public-private partnership, working to transform the future of gene therapy using the power of artificial intelligence (AI). We’re creating advanced AI-driven tools that will make it possible to treat genetic diseases with greater accuracy and safety, improving public health on a global scale.

Today, over 300 million people live with genetic diseases, many of whom don’t have access to effective  treatments. While gene editing holds great promise, current methods can sometimes cause unintended genetic changes. PRIME-AI aims to overcome these challenges by making gene-editing therapies more precise, safe, and effective—offering new possibilities for those who need it most.

At the heart of our project is the use of cutting-edge AI to improve guideRNA design, a critical part of gene editing that helps target specific genes. By enhancing the accuracy of this process, we can speed up the delivery of life-saving treatments, tailored to each patient’s unique needs.

By the end of our project, we plan to deliver an AI platform for designing guideRNAs, develop a new gene-editing technology, and create a system a validation system to ensure the precision of these tools. Together, these innovations will pave the way toward truly personalized medicine, helping to revolutionize the way we treat genetic diseases in the future.

Summary
Our project uses AI to design more precise guideRNAs, making gene therapies more effective. By improving the accuracy of gene editing, we aim to revolutionize treatments for genetic diseases, bringing us closer to treatments that are truly personalized.
Technology Readiness Level (TRL)
4 - 6
Time period
24 months
Partners