Comparison of two oral appliances in obstructive sleep apnea patients

Comparison of two mandibular advancement devices in mild to moderate obstructive sleep apnea patients

The study aims to determine the influence of oral appliance design on its efficacy and effectiveness in obstructive sleep apnea (OSA) patients. The project is a collaboration between the Academic Centre for Dentistry Amsterdam (ACTA) and VIVISOL NEDERLAND B.V..

Ineffective treatment of OSA, a highly prevalent condition (9% to 38% of the adult population), has large health consequences and is associated with enormous costs ($3.4 billion in the USA), both for the individual and for society. The proposed study focusses on effective treatment with oral appliances in OSA patients, in which case the individual’s performance will improve, both in his/her private life and at work. In addition, successfully treated OSA patients are also healthier and require less extensive and expensive, hospital-based diagnostics and treatments for their condition and its comorbidities. This will be beneficial for the society as a whole: better functioning individuals contribute to a healthier economy.

The study will give insight in which aspects of oral appliance therapy are crucial for a good efficacy and adherence in OSA patients. The outcome of this project will thus contribute to the realisation of an accessible and affordable management strategy for OSA.

In this project, the outcomes will lead to new knowledge for significant improvement of the current design of the oral appliance of VIVISOL NEDERLAND B.V., which will strengthen its position in the current (inter-)national market.

Obstructive sleep apnea (OSA) is characterised by repetitive obstructions of the upper airway during sleep. Currently, oral appliances are commonly prescribed for the treatment of OSA patients. This study focusses on effective treatment of OSA by comparing 2 different oral appliances with a special focus on patient preference.
Technology Readiness Level (TRL)
5 - 7
Time period
48 months