Health-Holland

The dynamic Life Sciences & Health sector in the Netherlands has a strong knowledge-base and a high concentration of innovative companies that contribute greatly to health and well-being around the globe. International research in Life Sciences & Health is beneficial to the development of health research programs in the Netherlands, extending and broadening the research domain beyond national boundaries. Horizon 2020 is an EU-broad research and innovation stimulus program with an 80 billion euro budget and it is one of the most successful European health initiatives. The Netherlands’ involvement in this program is extremely high, with Dutch participants involved in 49% of the initiatives in Horizon 2020 health research programs. Dutch SMEs and scientific institutions also participate in projects driven by the Innovative Medicines Initiative. The non-pro t organization Lygature supports the development of new medical solutions for patients by managing public-private partnerships involving academia, industry and society. An example of a successful PPP is the European Lead Factory, whose mission is to deliver innovative drug discovery starting-points.The European Lead Factory has founded the European Compound Library and the European Screening Centre - a unique industry-standard uHTS platform offering free access to up to 500,000 novel compounds. The impact of the European Lead Factory to-date has been impressive: • Total budget 2013-2018: 196 million euros • 30 participants from 15 European countries • 150 employees from public partners involved • > 40 million data points collected on possible drug candidates • > 6.000 high-quality hit compounds identified for >120 innovative disease targets • > 60 scientific articles in high-impact journals • Featured three times in Nature reviews drug discovery • Two start-ups launched based on results from the European Lead Factory International health initiatives “The European Lead Factory is definitely the type of platform we need in the European ecosystem.” Jemila Houacine , Associate, Investment team at Medicxi Ventures, Switzerland 18

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