LSH-FES Consortia

The field of Regenerative Medicine is diverse. The Netherlands Institute of Regenerative Medicine (NIRM) has therefore focused its research on five main areas, selected on the basis of knowledge and expertise of the associated researchers: Cardiovascular, Muscles and bones, Blood, Central nervous system, Internal medicine.

Research within NIRM is performed at different levels, from DNA to proteins and from cells to tissue. Because of this breadth, and the extensive contacts between researchers in these different areas, NIRM is able to expand the knowledge of stem cells and regenerative medicine as efficiently as possible.

The knowledge and research of NIRM are of significant interest to non-scientific readers. That is why NIRM also has a website for the general public.

Acute respiratory viral infections, acute enteric viral infections, chronic hepatitis B, C and E infections and HIV infections together constitute the majority, in terms of disease burden, of infectious diseases in the Netherlands and beyond.

The VIRGO Consortium focusses on the rational design of novel and/or improved intervention strategies against these major viral infectious diseases. In addition, VIRGO includes pioneering research on neurological disorders with suspected viral origin. By studying the interaction between viruses and their host at a molecular level, we aim to develop new ways to interfere in the infection processes, prevent infection by developing vaccines, diagnose and cure infections.

To achieve these goals the public private partnership contains 7 academic institutions, 3 research organizations and 10 industrial companies who together form the frontrunners in this field in The Netherlands.

NeuroBasic-PharmaPhenomics - 
The development of the next generation of neuropharmaceutical drugs has been difficult to achieve. Generation and automation of high-throughput and highcontent assays to assess CNS drug effects have been formidable challenges.

Increasing fundamental knowledge of complex signal transduction pathways in the brain resulted in the identification of candidate genes for major brain disorders and the generation of targeted genetic mouse models for brain diseases. Novel opportunities are emerging.

NeuroBasic-PharmaPhenomics wants to build new rodent models of neurological and psychiatric diseases and translate pre-clinical studies of animal models into novel treatments for human patients.

DCTI is a research initiative to improve beta-cell replacement therapy and to make this therapy accessible for more patients with diabetes. The main research goals are to increase the availability of high quality islets for transplantation, identify factors for long-term islet function and survival, and to develop alternative transplantation sites with the use of biomaterials.

Cyttron II -  
Towards better diagnostic tools: integrating bioimaging technologies

How can molecular alterations affect the healthy state of a human being? It is essential to understand this in order to develop new diagnostics and treatments. Yet answering this question requires an all embracing picture – from molecules to cells to organs to organisms.

Current bioimaging tools can only reveal the important aspects on one single level. In Cyttron II tools are developed and the quantitative data of complementary bioimaging technologies are integrated in order to understand the whole picture.

tEPIS: part of the CTMM “TraIT” project  
The mission of tEPIS is to create an online virtual microscopy platform that allows researchers and pathologists to share and store pathology slides and data, and facilitate image and data analysis. Read more here